Thrombospondin-5 Antibody (YA10096)
(Synonyms: Cartilage oligomeric matrix protein, COMP, Thrombospondin-5, TSP5)Thrombospondin-5 Antibody (YA10096) is a Mouse-derived and non-conjugated IgG1 monoclonal antibody, targeting to Thrombospondin-5.
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Host:
Rabbit
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Isotype:
IgG1
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Application:
WB, IHC-P
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Reactivity :
Human, Mouse, Rat
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Formulation:
Supplied in PBS (pH 7.4), containing 30% glycerol, and 0.01% sodium azide.
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Conjugation:
Non-conjugated
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Applications
| Application |
WB
WB: Western Blot
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IHC-P
IHC-P: Immunohistochemistry-Paraffin
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|---|---|---|
| Dilution Ratio | 1:1000-2000 | 1:200-400 |
Product Details
Thrombospondin-5 Antibody (YA10096) is a Mouse-derived and non-conjugated IgG1 monoclonal antibody, targeting to Thrombospondin-5.
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Host Rabbit
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Clonality Polyclonal
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Species ReactivityHuman, Mouse, Rat
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Calculated Molecular Weight Predicted band size: 82 kDa
Purified synthetic peptide of human Thrombospondin-5(aa320-370).
Endogenous
affinity purified.
Non-conjugated
Unmodified
IgG1
Product Properties
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Appearance
Solution
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Formulation
Supplied in PBS (pH 7.4), containing 30% glycerol, and 0.01% sodium azide.
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Storage & Stability
Stored at -20°C for 1 year. Avoid repeated freeze / thaw cycles.
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Shipping
Shipping with blue ice.
Background
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Function
Thrombospondin-5 plays a role in the structural integrity of cartilage via its interaction with other extracellular matrix proteins such as the collagens and fibronectin. Can mediate the interaction of chondrocytes with the cartilage extracellular matrix through interaction with cell surface integrin receptors. Could play a role in the pathogenesis of osteoarthritis. Potent suppressor of apoptosis in both primary chondrocytes and transformed cells. Suppresses apoptosis by blocking the activation of caspase-3 and by inducing the IAP family of survival proteins (BIRC3, BIRC2, BIRC5 and XIAP). Essential for maintaining a vascular smooth muscle cells (VSMCs) contractile/differentiated phenotype under physiological and pathological stimuli. Maintains this phenotype of VSMCs by interacting with ITGA7 (By similarity)[1][2][3].
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Subcellular Localization
Secreted, extracellular space, extracellular matrix
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Expression
Tissue_Specificity: Abundantly expressed in the chondrocyte extracellular matrix, and is also found in bone, tendon, ligament and synovium and blood vessels. Increased amounts are produced during late stages of osteoarthritis in the area adjacent to the main defect. -
Isoforms & Post-Translational Modification
Thrombospondin-5 has 2 isoforms, P49747-1: amino acid length is 757, molecular weight is 82860 Da (predicted); P49747-2: amino acid length is 704, molecular weight is 77214 Da (predicted).被金属蛋白酶 ADAMTS4 和 ADAMTS1 蛋白水解切割，其中 ADAMTS4 的活性更强Thrombospondin-5 存在 2 个异构体，P49747-1：氨基酸个数为 757 个，分子量为 82860 Da (预测)；P49747-2：氨基酸个数为 704 个，分子量为 77214 Da (预测)。Proteolytically cleaved by metalloproteases ADAMTS4 and ADAMTS1 with ADAMTS4 showing more potent activity
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Subunit
Pentamer; disulfide-linked.
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SwissProt ID
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Synonyms
Cartilage oligomeric matrix protein, COMP, Thrombospondin-5, TSP5
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