FLT3-IN-19
Based on 1 Customer Validation
FLT3-IN-19 (Comp 50) is a potent and selective FLT3 inhibitor with IC50 of 0.213 nM. FLT3-IN-19 can be used in AML disease research.
Para uso exclusivo en investigación. No vendemos a pacientes.
- Pureza: 99.19%
- No. CAS: 2237234-48-7
- Fòrmula: C22H26N8O
- Peso molecular:418.49
-
Almacenamiento:Powder -20°C, 3 years , 4°C, 2 years ; In solvent -80°C, 6 months , -20°C, 1 month
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
-
Actividad biológica
-
Chemical Information
-
Solvente y solubilidad
- Pureza y Documentación
- Referencias
-
Help & FAQs
Actividad biológica
|
Cell Line
|
Type | Value | Description | References |
|---|---|---|---|---|
| HL-60 | IC50 |
0.334 μM
Compound: 50
|
Growth inhibition of human HL60 cells expressing low levels of FLT3 after 72 hrs by Cell-Titer Glo assay
Growth inhibition of human HL60 cells expressing low levels of FLT3 after 72 hrs by Cell-Titer Glo assay
|
[PMID: 29894944] |
| K562 | IC50 |
0.235 μM
Compound: 50
|
Growth inhibition of FLT3 null human K562 cells after 72 hrs by Cell-Titer Glo assay
Growth inhibition of FLT3 null human K562 cells after 72 hrs by Cell-Titer Glo assay
|
[PMID: 29894944] |
| MOLM-13 | IC50 |
0.039 μM
Compound: 50
|
Growth inhibition of human MOLM13 cells harboring FLT3-ITD after 72 hrs by Cell-Titer Glo assay
Growth inhibition of human MOLM13 cells harboring FLT3-ITD after 72 hrs by Cell-Titer Glo assay
|
[PMID: 29894944] |
| MV4-11 | IC50 |
0.016 μM
Compound: 50
|
Growth inhibition of human MV4-11 cells harboring FLT3-ITD after 72 hrs by Cell-Titer Glo assay
Growth inhibition of human MV4-11 cells harboring FLT3-ITD after 72 hrs by Cell-Titer Glo assay
|
[PMID: 29894944] |
Chemical Information
-
No. CAS 2237234-48-7
-
Appearance Solid
-
Peso molecular 418.49
-
Fòrmula C22H26N8O
-
Color Off-white to light yellow
-
SMILES
O=C(C1=NNC=C1NC2=NC(C)=NC3=C2CCC3)NC4=CC=C(N5CCNCC5)C=C4
-
Envío
Room temperature in continental US; may vary elsewhere.
-
Almacenamiento
Powder -20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month
Solvente y solubilidad
DMSO : 5 mg/mL (11.95 mM; ultrasonic and warming and heat to 60°C; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Pureza y Documentación
-
Ficha de datos (269 KB)
-
SDS (251 KB)
- English - EN (251 KB)
- Français - FR (251 KB)
- Deutsch - DE (251 KB)
- Norwegian - NO (251 KB)
- Español - ES (251 KB)
- Swedish - SV (251 KB)
- Italian - IT (251 KB)
- Korean - KR (251 KB)
- Portuguese - PT (251 KB)
-
Instrucciones de manejo (2659 KB)
Referencias
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO | 1 mM | 2.3895 mL | 11.9477 mL | 23.8954 mL | 59.7386 mL |
| 5 mM | 0.4779 mL | 2.3895 mL | 4.7791 mL | 11.9477 mL | |
| 10 mM | 0.2390 mL | 1.1948 mL | 2.3895 mL | 5.9739 mL |
FLT3-IN-19 Related Classifications
HY-153473 Related Classifications
Powered by Bioz