ESD - esterase D Gene

Also Known as FGH

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 2098

About ESD

Cytogenetic location: 13q14.2 Genomic coordinates (GRCh38): 13:46,771,256-46,797,700 (from NCBI)

This gene has 5 transcripts (splice variants) and 245 orthologues. Ubiquitous expression in thyroid (RPKM 31.6), ovary (RPKM 31.3) and 25 other tissues.

Summary

This gene encodes a serine hydrolase that belongs to the esterase D family. The encoded enzyme is active toward numerous substrates including O-acetylated sialic acids, and it may be involved in the recycling of sialic acids. This gene is used as a genetic marker for retinoblastoma and Wilson's disease. [provided by RefSeq, Feb 2009]

ESD Products (1)

mRNA Protein Name
NM_001984.2 NP_001975.1 S-formylglutathione hydrolase

Gene Ontology

  • Molecular Function
Molecular Function GO Annotation Evidence Verweise Source
enables hydrolase activity, acting on ester bonds IDA
IDA: Inferred from direct assay
19126594 GOA
enables identical protein binding IPI
IPI: Inferred from physical interaction
25416956 GOA
enables protein binding IPI
IPI: Inferred from physical interaction
25416956 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

ESD Protein Structure

Esterase

Esterase: Putative esterase (23 - 274)

  • 0
  • 100
  • 200
  • 282 a.a.
Protein Preferred Names Protein Names

S-formylglutathione hydrolase

  • esterase 10

ESD Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method Verweise
Intra
ESD P10768 FSD2 Homo sapiens A1L4K1
Y2H Array
25416956
Intra
ESD P10768 ESD Homo sapiens P10768
Y2H Prey Pooling
32296183
Intra
ESD P10768 PLCG2 Homo sapiens P16885
Y2H Array
25814554
Intra
ESD P10768 FSD2 Homo sapiens A1L4K1
Y2H Array
32296183
Intra
ESD P10768 ESD Homo sapiens P10768
Y2H Array
31515488
Intra
ESD P10768 FSD2 Homo sapiens A1L4K1
Y2H Array
31515488
Intra
ESD P10768 ESD Homo sapiens P10768
Validated Y2H
32296183
Intra
ESD P10768 CRK Homo sapiens P46108
Y2H Array
25814554
Intra
ESD P10768 FSD2 Homo sapiens A1L4K1
Validated Y2H
25416956
Intra
ESD P10768 FSD2 Homo sapiens A1L4K1
Y2H Prey Pooling
32296183
Intra
ESD P10768 ESD Homo sapiens P10768
Y2H Array
32296183
Intra
ESD P10768 ESD Homo sapiens P10768
Y2H Array
25416956
Cross: Cross-species interaction Intra: Intraspecies interaction

Recombinant ESD Proteins

Art. -Nr. Produktname Accession Reinheit
HY-P70279 Esterase D/FGH Protein, Human (His) AAH01169.1 (M1-A282) ≥ 95%, as determined by reducing SDS-PAGE.

ESD Antibodies

Art. -Nr. Produktname Anwendung Reactivity
HY-P811232 ESD Antibody WB, IHC-P Human, Mouse, Rat
HY-P86867 ESD Antibody (YA6560) WB Human, Mouse, Rat

Related Diseases

Diseases Alias
Wilson Disease

  • Hepatolenticular Degeneration

  • WD

  • Wilson'S Disease

  • WND

  • Westphal-Strumpell Syndrome

  • Copper Storage Disease

  • Cerebral Pseudosclerosis

  • Westphal Pseudosclerosis

  • Hepatolenticular Degeneration Syndrome

  • Copper Retention

  • Hepatocerebral Degeneration

  • Kinnier-Wilson Disease

  • Neurohepatic Degeneration

  • Progressive Hepatolenticular Degeneration

  • Lenticular Degenerative Disease

  • Wilson'S Syndrome

  • Lenticular Syndrome
Retinoblastoma

  • RB

  • Trilateral Retinoblastoma

  • RB1

  • Retinoblastoma, Trilateral

  • Neuroblastoma Of Retina

  • Rb - Retinoblastoma

  • Eye Cancer, Retinoblastoma

  • Retinal Cancer

  • Retinal Tumor

  • Glioma, Retinal

  • Non-Hereditary Retinoblastoma

  • Childhood Cancer Retinoblastoma

  • Malignant Neoplasm Of Retina

  • Retinal Neoplasms
Cervical Non-Keratinizing Squamous Cell Carcinoma
Dermoid Cyst Of Ovary

  • Dermoid Cyst

  • Ovarian Dermoid Cyst

  • Teratoma, Ovarian
Bilateral Retinoblastoma
Familial Retinoblastoma

  • Hereditary Retinoblastoma

  • Retinoblastoma
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (3)
Art. -Nr. Produktname
Wirkung
Reinheit
Rare Diseases
HY-RS04524 ESD Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS19859 Esd Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS26359 Esd Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Mus musculus ESD MGD MGI:95421
Felis catus ESD VGNC VGNC:102197
Bos taurus ESD VGNC VGNC:28600
Rattus norvegicus ESD RGD RGD:1592114
Canis familiaris ESD VGNC VGNC:40472
Macaca mulatta ESD VGNC VGNC:103814
Others ESD NCBI