A-841720
Based on 1 Customer Validation
A-841720 is a potent, non-competitive and selective mGlu1 receptor antagonist with an IC50 of 10 nM for human mGlu1 receptor. A-841720 displays 34-fold selectivity over mGlu5 (IC50 of 342 nM), and no significant activity at a range of other neurotransmitter receptors, ion channels, and transporters. A-841720 has the potential for chronic pain research.
For research use only. We do not sell to patients.
- Purity: 98.0%
- CAS No.: 869802-58-4
- Formula: C17H21N5OS
- Molecular Weight:343.45
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Storage:
-20°C, protect from light, stored under nitrogen
* In solvent : -80°C, 6 months; -20°C, 1 month (protect from light, stored under nitrogen)
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biological Activity
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Chemical Information
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Solvent & Solubility
- Purity & Documentation
- References
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Help & FAQs
Biological Activity
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Human mGluR1 10 nM (IC50) |
human mGluR5 342 nM (IC50) |
Chemical Information
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CAS No. 869802-58-4
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Appearance Solid
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Molecular Weight 343.45
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Formula C17H21N5OS
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Color White to off-white
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SMILES
O=C1C2=C(C3=C(N(C)C)C=CN=C3S2)N=CN1N4CCCCCC4
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
-20°C, protect from light, stored under nitrogen
* In solvent : -80°C, 6 months; -20°C, 1 month (protect from light, stored under nitrogen)
Solvent & Solubility
DMSO : 15 mg/mL (43.67 mM; Need ultrasonic and warming; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light, stored under nitrogen). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light, stored under nitrogen). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Purity & Documentation
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Data Sheet (275 KB)
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SDS (252 KB)
- English - EN (252 KB)
- Français - FR (252 KB)
- Deutsch - DE (252 KB)
- Norwegian - NO (252 KB)
- Español - ES (252 KB)
- Swedish - SV (252 KB)
- Italian - IT (252 KB)
- Korean - KR (252 KB)
- Portuguese - PT (252 KB)
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Handling Instructions (2659 KB)
References
[1]. O El-Kouhen, et al. Blockade of mGluR1 receptor results in analgesia and disruption of motor and cognitive performances: effects of A-841720, a novel non-competitive mGluR1 receptor antagonist. Br J Pharmacol. 2006 Nov;149(6):761-74. [Content Brief]
[2]. Lorenzo Morè, et al. Comparison of the mGluR1 antagonist A-841720 in rat models of pain and cognition. Behav Pharmacol. 2007 Jul;18(4):273-81. [Content Brief]
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light, stored under nitrogen). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO | 1 mM | 2.9116 mL | 14.5582 mL | 29.1163 mL | 72.7908 mL |
| 5 mM | 0.5823 mL | 2.9116 mL | 5.8233 mL | 14.5582 mL | |
| 10 mM | 0.2912 mL | 1.4558 mL | 2.9116 mL | 7.2791 mL | |
| 15 mM | 0.1941 mL | 0.9705 mL | 1.9411 mL | 4.8527 mL | |
| 20 mM | 0.1456 mL | 0.7279 mL | 1.4558 mL | 3.6395 mL | |
| 25 mM | 0.1165 mL | 0.5823 mL | 1.1647 mL | 2.9116 mL | |
| 30 mM | 0.0971 mL | 0.4853 mL | 0.9705 mL | 2.4264 mL | |
| 40 mM | 0.0728 mL | 0.3640 mL | 0.7279 mL | 1.8198 mL |
A-841720 Related Classifications
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