CP 80080
CP 80080 is a Topoisomerase II ligand with almost no ability to stimulate topoisomerase II-mediated DNA cleavage. CP 80080 competes with DNA cleavage-enhancing antineoplastic agents for a common binding domain on Drosophila topoisomerase II, thereby attenuating the ability of these agents to stimulate topoisomerase II-mediated DNA cleavage. CP 80080 can be used in cancer-related research.
For research use only. We do not sell to patients.
- CAS No.: 152247-02-4
- Formula: C20H16FNO4
- Molecular Weight:353.34
-
Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
-
Biological Activity
-
Chemical Information
- Purity & Documentation
- References
-
Help & FAQs
Biological Activity
|
Topoisomerase II |
Chemical Information
-
CAS No. 152247-02-4
-
Molecular Weight 353.34
-
Formula C20H16FNO4
-
SMILES
O=C(C1=CN(C2CC2)C3=C(C=C(F)C(C4=CC=C(OC)C=C4)=C3)C1=O)O
-
Shipping
Room temperature in continental US; may vary elsewhere.
-
Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
[1]. Elsea SH, et al. Quinolones share a common interaction domain on topoisomerase II with other DNA cleavage-enhancing antineoplastic drugs. Biochemistry. 1997 Mar 11;36(10):2919-24. [Content Brief]
[2]. Osheroff N, et al. Defining functional drug-interaction domains on topoisomerase II by exploiting mechanistic differences between drug classes. Cancer chemotherapy and pharmacology. 1994;34 Suppl:S19-25. [Content Brief]
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
CP 80080 Related Classifications
HY-124336 Related Classifications
Powered by Bioz