152247-02-4
Chemical Structure
CP 80080
- CAS No.: 152247-02-4
- Formula:C20H16FNO4
- Molecular Weight:353.34
IUPAC Name: 1-cyclopropyl-6-fluoro-7-(4-methoxyphenyl)-4-oxo-1,4-dihydroquinoline-3-carboxylic acid
InChIKey: LIPHLGKSAYFDAO-UHFFFAOYSA-N
SMILES: O=C(C1=CN(C2CC2)C3=C(C=C(F)C(C4=CC=C(OC)C=C4)=C3)C1=O)O
Biological Activity: CP 80080 is a Topoisomerase II ligand with almost no ability to stimulate topoisomerase II-mediated DNA cleavage. CP 80080 competes with DNA cleavage-enhancing antineoplastic agents for a common binding domain on Drosophila topoisomerase II, thereby attenuating the ability of these agents to stimulate topoisomerase II-mediated DNA cleavage. CP 80080 can be used in cancer-related research[1][2].
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CP 80080 | CP 80080 is a Topoisomerase II ligand with almost no ability to stimulate topoisomerase II-mediated DNA cleavage. CP 80080 competes with DNA cleavage-enhancing antineoplastic agents for a common binding domain on Drosophila topoisomerase II, thereby attenuating the ability of these agents to stimulate topoisomerase II-mediated DNA cleavage. CP 80080 can be used in cancer-related research. | |||||||||||||||||||||
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References
- [1]. Elsea SH, et al. Quinolones share a common interaction domain on topoisomerase II with other DNA cleavage-enhancing antineoplastic drugs. Biochemistry. 1997 Mar 11;36(10):2919-24. [Content Brief]
- [2]. Osheroff N, et al. Defining functional drug-interaction domains on topoisomerase II by exploiting mechanistic differences between drug classes. Cancer chemotherapy and pharmacology. 1994;34 Suppl:S19-25. [Content Brief]
