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Cat. No.: HY-124336

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CP 80080

CP 80080 is a Topoisomerase II ligand with almost no ability to stimulate topoisomerase II-mediated DNA cleavage. CP 80080 competes with DNA cleavage-enhancing antineoplastic agents for a common binding domain on Drosophila topoisomerase II, thereby attenuating the ability of these agents to stimulate topoisomerase II-mediated DNA cleavage. CP 80080 can be used in cancer-related research.

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CAS No.: 152247-02-4
Formule: C₂₀H₁₆FNO₄
Masse moléculaire:353.34

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Please store the product under the recommended conditions in the Certificate of Analysis.

CP 80080 Chemical Structure

CAS No.: 152247-02-4

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Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

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Description

IC₅₀ & Target^[1]

Topoisomerase II

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Chemical Information

CAS No. 152247-02-4
Masse moléculaire 353.34
Formule C₂₀H₁₆FNO₄
SMILES

O=C(C1=CN(C2CC2)C3=C(C=C(F)C(C4=CC=C(OC)C=C4)=C3)C1=O)O
Livraison

Room temperature in continental US; may vary elsewhere.
Stockage

Please store the product under the recommended conditions in the Certificate of Analysis.

Pureté et documentation

Instruction de manipulation (2659 KB)

Références

[1]. Elsea SH, et al. Quinolones share a common interaction domain on topoisomerase II with other DNA cleavage-enhancing antineoplastic drugs. Biochemistry. 1997 Mar 11;36(10):2919-24. [Content Brief]

[2]. Osheroff N, et al. Defining functional drug-interaction domains on topoisomerase II by exploiting mechanistic differences between drug classes. Cancer chemotherapy and pharmacology. 1994;34 Suppl:S19-25. [Content Brief]

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How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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CP 80080

Voir tous les produits spécifiques à Isoform Topoisomerase

Voir tous les produits spécifiques à Isoform DNA/RNA Synthesis

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Chemical Information

Pureté et documentation

Références

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CP 80080 Related Classifications

HY-124336 Related Classifications