1. GPCR/G Protein
    Neuronal Signaling
  2. 5-HT Receptor
  3. BIMU 8

BIMU 8 

Cat. No.: HY-110094
Handling Instructions

BIMU 8 is a potent and selective 5-HT4 agonist with EC50s of 18 nM, 77 nM, and 540 nM for wild type 5HT4 receptor, T3.36A, and W6.48A mutant 5-HT4 receptors.

For research use only. We do not sell to patients.

BIMU 8 Chemical Structure

BIMU 8 Chemical Structure

CAS No. : 134296-40-5

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Description

BIMU 8 is a potent and selective 5-HT4 agonist with EC50s of 18 nM, 77 nM, and 540 nM for wild type 5HT4 receptor, T3.36A, and W6.48A mutant 5-HT4 receptors[1][2].

IC50 & Target[2]

5-HT4 Receptor

18 nM (EC50)

T3.36A-5-HT4

77 nM (EC50)

W6.48A-5-HT4

540 nM (EC50)

In Vitro

In myenteric neurons of guinea pig ileum, BIMU 8 (0.003-0.1 µM) increases excitatory postsynaptic potentials (EPSPs) mplitude but does not change the membrane potential of any neuron[3].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

In Vivo

In mice and rats, BIMU 8 (20-30 mg/kg s.c. and 60 mg/kg p.o. in mice; 20 mg/kg i.p. in rats), produces significant antinociception. Intracerebroventricular injection in mice of BIMU 8 (10 μg/mouse), doses which are largely ineffective by parenteral routes, induces an antinociception whose intensity equaled that obtainable s.c., i.p. or p.o[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Molecular Weight

377.89

Formula

C₁₉H₂₆ClN₄O₂-

CAS No.
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Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

References
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BIMU 8
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HY-110094
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