134296-40-5
134296-40-5
Chemical Structure
BIMU 8
- CAS No.: 134296-40-5
- Formula:C19H27ClN4O2
- Molecular Weight:378.90
IUPAC Name: 3-isopropyl-N-((1R,3r,5S)-8-methyl-8-azabicyclo[3.2.1]octan-3-yl)-2-oxo-2,3-dihydro-1H-benzo[d]imidazole-1-carboxamide, chloride salt
InChIKey: NQYXXIUVFVOJCX-NFWSUKNGSA-M
SMILES: CN([C@](CC1)([H])C2)[C@@]1([H])C[C@@H]2NC(N3C4=CC=CC=C4N(C3=O)C(C)C)=O.Cl
Biological Activity: BIMU 8 is a potent and selective 5-HT4 agonist with EC50s of 18 nM, 77 nM, and 540 nM for wild type 5HT4 receptor, T3.36A, and W6.48A mutant 5-HT4 receptors[1][2].
| Cat. No. | 상품명 | Purity | 제품 설명 | Pricing | |||||||||||||||||||
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BIMU 8 | 99.60% | BIMU 8 is a potent and selective 5-HT4 agonist with EC50s of 18 nM, 77 nM, and 540 nM for wild type 5HT4 receptor, T3.36A, and W6.48A mutant 5-HT4 receptors. | ||||||||||||||||||||
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References
- [1]. C Ghelardini, et al. Central cholinergic antinociception induced by 5HT4 agonists: BIMU 1 and BIMU 8. Life Sci. 1996;58(25):2297-309. [Content Brief]
- [2]. Lucie P Pellissier, et al. Conformational toggle switches implicated in basal constitutive and agonist-induced activated states of 5-hydroxytryptamine-4 receptors. Mol Pharmacol. 2009 Apr;75(4):982-90. [Content Brief]
