2. GPCR/G Protein Neuronal Signaling
  3. CGRP Receptor
  4. BMS-846372

BMS-846372 (Compound 5) is an orally active CGRP antagonist (Ki = 0.07 nM). BMS-846372 may be used in migraine research.

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BMS-846372

BMS-846372 Chemische Struktur

CAS. Nr. : 1190363-03-1

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BMS-846372 Related Antibodies

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Beschreibung

BMS-846372 (Compound 5) is an orally active CGRP antagonist (Ki = 0.07 nM). BMS-846372 may be used in migraine research[1][2].

Cellular Effect
Cell Line Type Value Description References
SK-N-MC IC50
0.22 nM
Compound: 5, BMS-846372
Antagonist activity at CGRP receptor in human SK-N-MC cells assessed as inhibition of CGRP-stimulated cAMP production
Antagonist activity at CGRP receptor in human SK-N-MC cells assessed as inhibition of CGRP-stimulated cAMP production
[PMID: 24900474]
Molekulargewicht

519.54

Formel

C28H27F2N5O3
CAS. Nr.
SMILES

O=C(N1CCC(N(C2=CC=CN=C2N3)C3=O)CC1)O[C@@H]4CC[C@@H](C5=CC=CC(F)=C5F)CC6=CC=CN=C64
Versand

Room temperature in continental US; may vary elsewhere.
Speicherung

Please store the product under the recommended conditions in the Certificate of Analysis.
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BMS-846372 Related Classifications

  • Molaritätsrechner

  • Verdünnungsrechner

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Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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The dilution calculator equation

Konzentration (Stammlösung) × Volumen (Stammlösung) = Konzentration (Ziellösung) × Volumen (Ziellösung)

Diese Gleichung wird häufig abgekürzt als: C1V1 = C2V2

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

BMS-8463721190363-03-1BMS846372BMS 846372CGRP ReceptorCalcitonin gene-related peptide receptorCGRP antagonistmigraineInhibitorinhibitorinhibit

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