1190363-03-1
1190363-03-1
Chemical Structure
BMS-846372
- CAS No.: 1190363-03-1
- Formula:C28H27F2N5O3
- Molecular Weight:519.54
IUPAC Name: (6R,9R)-6-(2,3-difluorophenyl)-6,7,8,9-tetrahydro-5H-cyclohepta[b]pyridin-9-yl 4-(2-oxo-2,3-dihydro-1H-imidazo[4,5-b]pyridin-1-yl)piperidine-1-carboxylate
InChIKey: VUNYPRIWWJSQTR-UZUQRXQVSA-N
SMILES: O=C(N1CCC(N(C2=CC=CN=C2N3)C3=O)CC1)O[C@@H]4CC[C@@H](C5=CC=CC(F)=C5F)CC6=CC=CN=C64
Biological Activity: BMS-846372 (Compound 5) is an orally active CGRP antagonist (Ki = 0.07 nM). BMS-846372 may be used in migraine research[1][2].
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BMS-846372 | BMS-846372 (Compound 5) is an orally active CGRP antagonist (Ki = 0.07 nM). BMS-846372 may be used in migraine research. | |||||||||||||||||||||
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References
- [1]. Leahy DK, et al. Efficient and scalable enantioselective synthesis of a CGRP antagonist. Org Lett. 2012 Sep 21;14(18):4938-41. [Content Brief]
- [2]. Luo G, et al. Discovery of BMS-846372, a Potent and Orally Active Human CGRP Receptor Antagonist for the Treatment of Migraine. ACS Med Chem Lett. 2012 Feb 27;3(4):337-41. [Content Brief]
Keywords
