1. GPCR/G Protein
    Neuronal Signaling
  2. mGluR
  3. BMS-984923

BMS-984923 

Cat. No.: HY-122559
Handling Instructions

BMS-984923, a potent mGluR5 silent allosteric modulator (SAM), with exquisite binding affinity (Ki = 0.6 nM), exhibits good oral bioavailability and BBB penetration. BMS-984923 potently inhibits the PrPC-mGluR5 interaction and prevents pathological Aβo signaling without affecting physiological glutamate signaling.

For research use only. We do not sell to patients.

BMS-984923 Chemical Structure

BMS-984923 Chemical Structure

CAS No. : 1375752-78-5

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Description

BMS-984923, a potent mGluR5 silent allosteric modulator (SAM), with exquisite binding affinity (Ki = 0.6 nM), exhibits good oral bioavailability and BBB penetration. BMS-984923 potently inhibits the PrPC-mGluR5 interaction and prevents pathological Aβo signaling without affecting physiological glutamate signaling[1].

In Vivo

BMS-984923 (7.5 mg/kg or 15 mg/kg, oral gavage, once) exhibits good oral bioavailability and BBB penetration[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: C57Bl6J male mice[1].
Dosage: 7.5 mg/kg or 15 mg/kg (Pharmacokinetic Analysis)
Administration: Oral gavage, once.
Result: The plasma concentration exceeded 2 μM at 10 hr. Brain concentrations were nearly as high as plasma concentrations when measured 3 hr after a 7.5 mg/kg oral dose
Molecular Weight

374.82

Formula

C₂₂H₁₅ClN₂O₂

CAS No.

1375752-78-5

SMILES

O=C1O[[email protected]](C2=CC=CC=C2Cl)[[email protected]@H](C3=CC(C#CC4=CC=CC=C4)=CN=C3)N1

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

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Keywords:

BMS-984923BMS984923BMS 984923mGluRMetabotropic glutamate receptorsAlzheimer'sdiseaseSAMAβoInhibitorinhibitorinhibit

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BMS-984923
Cat. No.:
HY-122559
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