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Cat. No.: HY-N9194

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5-Methoxycanthin-6-one

5-Methoxycanthin-6-one is an orally active inhibitor of Leishmania strains. 5-Methoxycanthin-6-one shows cytotoxicity with an IC₅₀ of 5.44 μg/mL against Ailanthus altissima cells.

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CAS No.: 15071-56-4
Formule: C₁₅H₁₀N₂O₂
Masse moléculaire:250.25

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Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (279 KB)

5-Methoxycanthin-6-one Chemical Structure

CAS No.: 15071-56-4

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Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Activité biologique
- Description
- IC₅₀ & Target
- Cellular Effect
Chemical Information
Pureté et documentation
Références
Calculators
Help & FAQs
Classifications
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Activité biologique

Description

5-Methoxycanthin-6-one is an orally active inhibitor of Leishmania strains. 5-Methoxycanthin-6-one shows cytotoxicity with an IC₅₀ of 5.44 μg/mL against Ailanthus altissima cells^[1]^[2].

IC₅₀ & Target

Leishmania

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Cellular Effect

Cell Line	Type	Value	Description	References
A549	ED₅₀	3.1 μg/mL Compound: 6	Cytotoxicity against human A549 cells after 3 days by SRB assay Cytotoxicity against human A549 cells after 3 days by SRB assay	[PMID: 11141127]
CAKI-1	ED₅₀	4.4 μg/mL Compound: 6	Cytotoxicity against human CAKI1 cells after 3 days by SRB assay Cytotoxicity against human CAKI1 cells after 3 days by SRB assay	[PMID: 11141127]
HCT-8	ED₅₀	2.5 μg/mL Compound: 6	Cytotoxicity against human HCT8 cells after 3 days by SRB assay Cytotoxicity against human HCT8 cells after 3 days by SRB assay	[PMID: 11141127]
KB	ED₅₀	2.9 μg/mL Compound: 6	Cytotoxicity against human KB cells after 3 days by SRB assay Cytotoxicity against human KB cells after 3 days by SRB assay	[PMID: 11141127]
MCF7	ED₅₀	5 μg/mL Compound: 6	Cytotoxicity against human MCF7 cells after 3 days by SRB assay Cytotoxicity against human MCF7 cells after 3 days by SRB assay	[PMID: 11141127]
SK-MEL-2	ED₅₀	17 μg/mL Compound: 6	Cytotoxicity against human SK-MEL-2 cells after 3 days by SRB assay Cytotoxicity against human SK-MEL-2 cells after 3 days by SRB assay	[PMID: 11141127]

Chemical Information

CAS No. 15071-56-4
Masse moléculaire 250.25
Formule C₁₅H₁₀N₂O₂
SMILES

O=C1N2C3=C(N=CC=C3C4=C2C=CC=C4)C=C1OC
Structure Classification
- Alkaloids
- Pyridine Alkaloids
- Alkaloids
- Indole Alkaloids
Initial Source
Livraison

Room temperature in continental US; may vary elsewhere.
Stockage

Please store the product under the recommended conditions in the Certificate of Analysis.

Pureté et documentation

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Pureté: 99.98%

Assay: 99.98%

ee.: 99.98%

Fiche technique (279 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Instruction de manipulation (2659 KB)

Références

[1]. Ferreira ME, et al. Leishmanicidal activity of two canthin-6-one alkaloids, two major constituents of Zanthoxylum chiloperone var. angustifolium. J Ethnopharmacol. 2002 May;80(2-3):199-202. [Content Brief]

[2]. Anderson LA, et al. Production of cytotoxic canthin-6-one alkaloids by Ailanthus altissima plant cell cultures. J Nat Prod. 1983 May-Jun;46(3):374-8. [Content Brief]

Calculators

Calculateur de molarité

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Molecular Weight Molecular Weight

Calculateur de dilution

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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100 mg

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Activité biologique
- Description
- IC₅₀ & Target
Chemical Information
Pureté et documentation
Références

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5-Methoxycanthin-6-one

Voir tous les produits spécifiques à Isoform Parasite

Activité biologique

Chemical Information

Pureté et documentation

Références

Calculators

Help & FAQs

5-Methoxycanthin-6-one Related Classifications

HY-N9194 Related Classifications