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Lenalidomide hydrochloride

(Synonyms: CC-5013 hydrochloride)
63 Cited Publications
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Based on 63 publication(s) in Google Scholar

Lenalidomide hydrochloride (CC-5013 hydrochloride), a derivative of Thalidomide, acts as molecular glue. Lenalidomide hydrochloride is an orally active immunomodulator. Lenalidomide hydrochloride (CC-5013 hydrochloride) is a ligand of ubiquitin E3 ligase cereblon (CRBN), and it causes selective ubiquitination and degradation of two lymphoid transcription factors, IKZF1 and IKZF3, by the CRBN-CRL4 ubiquitin ligase. Lenalidomide hydrochloride (CC-5013 hydrochloride) specifically inhibits growth of mature B-cell lymphomas, including multiple myeloma, and induces IL-2 release from T cells.

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  • CAS No.: 1243329-97-6
  • Formule: C13H14ClN3O3
  • Masse moléculaire:295.72
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    Please store the product under the recommended conditions in the Certificate of Analysis.

  • Lenalidomide hydrochloride Chemical Structure
    Lenalidomide hydrochloride Chemical Structure
  • Experimental Validation Results for Lenalidomide hydrochloride
  • Experimental Validation Results for Lenalidomide hydrochloride
  • Experimental Validation Results for Lenalidomide hydrochloride
  • Experimental Validation Results for Lenalidomide hydrochloride
  • Experimental Validation Results for Lenalidomide hydrochloride
CAS No.: 1243329-97-6
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  • Lenalidomide hydrochloride Chemical Structure
    Lenalidomide hydrochloride Chemical Structure
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    Lenalidomide hydrochloride purchased from MedChemExpress. Usage Cited in: Nat Cancer. 2022 May;3(5):595-613. [Abstract]

    Customer Validation
     Western blot analysis for IKAROS, CK1α and MENIN protein following treatment of MV4;11 human MLL-r AML cell line for 5 hours with increasing doses of Thalidomide, lenalidomide, Pomalidomide and iberdomide (10,100, 1000 nM), using ACTIN as a loading control.

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    Lenalidomide hydrochloride purchased from MedChemExpress. Usage Cited in: Cell. 2018 Sep 20;175(1):171-185.e25. [Abstract]

    Customer Validation
     WB analysis of MV4-11 cells treated for 6.5 hr with Lenalidomide, BTX161, A51, or A86 at the indicated concentrations or DMSO.

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    Lenalidomide hydrochloride purchased from MedChemExpress. Usage Cited in: Oncol Rep. 2018 Jun;39(6):2873-2880. [Abstract]

    Customer Validation
     Representative western blot membranes showing the expression levels of NF-κB p-p65 and H3 in nuclear protein and of NF-κB p65 and β-actin in total protein. β-actin and H3 are used as internal controls.

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    Lenalidomide hydrochloride purchased from MedChemExpress. Usage Cited in: Elife. 2018 Aug 1:7:e38430. [Abstract]

    Customer Validation
     H9 hESC are treated with increasing concentrations of Thalidomide, Lenalidomide, Pomalidomide, or DMSO as a control. Following 24 h of incubation, SALL4 and GAPDH protein levels are assessed by western blot analysis.

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    Lenalidomide hydrochloride purchased from MedChemExpress. Usage Cited in: Nat Commun. 2017 May 22:8:15398. [Abstract]

    Customer Validation
     HEK293T cells are treated with 50 μg/mL Cycloheximide and increasing concentrations of Lenalidomide, Thalidomide or with DMSO, and cells are incubated for 6 h. ZFP91 and GAPDH levels are detected using anti-ZFP91 or anti-GAPDH immunoblotting.

  • Lenalidomide hydrochloride