HDAC6-IN-45
HDAC6-IN-45 (Compound 15) is a selective inhibitor for HDAC6 with IC50 of 15.2 nM. HDAC6-IN-45 exhibits neurotrophic through the upregulation of GAP43 and Beta-3 tubulin markers. HDAC6-IN-45 activates the Nrf2 signaling pathway, reduces H2O2-induced ROS production, inhibits apoptosis in PC12, and exhibits neuroprotective efficacy in SCOP-induced zebrafish Alzheimer's Disease models. HDAC6-IN-45 exhibits antioxidant activity and good blood-brain barrier (BBB) permeability.
Nos produits utilisent uniquement pour la recherche. Nous ne vendons pas aux patients.
- CAS No.: 3048532-05-1
- Formule: C23H24FN3O2
- Masse moléculaire:393.45
-
Stockage:
Please store the product under the recommended conditions in the Certificate of Analysis.
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
-
Activité biologique
-
Chemical Information
- Pureté et documentation
- Références
-
Help & FAQs
Activité biologique
|
HDAC6 15.2 nM (IC50) |
HDAC3 13.6 μM (IC50) |
HDAC2 19.3 μM (IC50) |
HDAC1 28.2 μM (IC50) |
Chemical Information
-
CAS No. 3048532-05-1
-
Masse moléculaire 393.45
-
Formule C23H24FN3O2
-
SMILES
O=C(NO)C(C=C1)=CC=C1CN(CC2)CC3=C2C4=CC(F)=CC=C4N3CC5CC5
-
Livraison
Room temperature in continental US; may vary elsewhere.
-
Stockage
Please store the product under the recommended conditions in the Certificate of Analysis.
Pureté et documentation
Références
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
HDAC6-IN-45 Related Classifications
HY-161783 Related Classifications
Powered by Bioz