3048532-05-1
Chemical Structure
HDAC6-IN-45
- CAS No.: 3048532-05-1
- Formula:C23H24FN3O2
- Molecular Weight:393.45
InChIKey: AZOSQQGVKOJXRE-UHFFFAOYSA-N
SMILES: O=C(NO)C(C=C1)=CC=C1CN(CC2)CC3=C2C4=CC(F)=CC=C4N3CC5CC5
Biological Activity: HDAC6-IN-45 (Compound 15) is a selective inhibitor for HDAC6 with IC50 of 15.2 nM. HDAC6-IN-45 exhibits neurotrophic through the upregulation of GAP43 and Beta-3 tubulin markers. HDAC6-IN-45 activates the Nrf2 signaling pathway, reduces H2O2-induced ROS production, inhibits apoptosis in PC12, and exhibits neuroprotective efficacy in SCOP-induced zebrafish Alzheimer's Disease models. HDAC6-IN-45 exhibits antioxidant activity and good blood-brain barrier (BBB) permeability[1].
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HDAC6-IN-45 | HDAC6-IN-45 (Compound 15) is a selective inhibitor for HDAC6 with IC50 of 15.2 nM. HDAC6-IN-45 exhibits neurotrophic through the upregulation of GAP43 and Beta-3 tubulin markers. HDAC6-IN-45 activates the Nrf2 signaling pathway, reduces H2O2-induced ROS production, inhibits apoptosis in PC12, and exhibits neuroprotective efficacy in SCOP-induced zebrafish Alzheimer's Disease models. HDAC6-IN-45 exhibits antioxidant activity and good blood-brain barrier (BBB) permeability. | |||||||||||||||||||||
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