Methyl orsellinate
Based on 1 Customer Validation
Methyl orsellinate acts as an antiviral agent and insecticide. Methyl orsellinate exhibits enzyme inhibitory activity, with an IC50 of 59.6 µM against porcine leukocyte 5-lipoxygenase (5-LOX); it inhibits soybean 15-lipoxygenase (15-LOX), and shows weak inhibitory activity against acetylcholinesterase (AChE) and glutathione S-transferase (GST). Methyl orsellinate displays contact toxicity against adult Drosophila suzukii. Methyl orsellinate shows anti-HSV-1 activity. Methyl orsellinate can be used in studies related to *Drosophila suzukii* infestation and HSV-1 infection.
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- Pureté: 99.91%
- CAS No.: 3187-58-4
- Formule: C9H10O4
- Masse moléculaire:182.17
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Stockage:Powder -20°C, 3 years ; In solvent -80°C, 6 months , -20°C, 1 month
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Activité biologique
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Chemical Information
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Solvant et solubilité
- Pureté et documentation
- Références
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Help & FAQs
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Activité biologique
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5-LOX |
15-LOX |
AChE |
HSV-1 |
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Cell Line
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Type | Value | Description | References |
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| Vero | IC50 |
4.6 μg/mL
Compound: 26
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Cytotoxicity against African green monkey Vero cells by colorimetric assay
Cytotoxicity against African green monkey Vero cells by colorimetric assay
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[PMID: 33861594] |
Methyl orsellinate (0.1-1 mg/mL; 40 min) weakly inhibits acetylcholinesterase activity in Drosophila suzukii adult males and females, with IC50 values of 2.07 mg/mL and 1.69 mg/mL, respectively[1].
Methyl orsellinate (0.1-1 mg/mL; 30 min) potently inhibits glutathione S-transferase activity in Drosophila suzukii adult males and females, with IC50 values of 0.18 mg/mL and 0.80 mg/mL, respectively[1].
Methyl orsellinate (75 μg/mL; 72 h) exhibits cytotoxicity against Vero cells with a CC50 of 75 μg/mL[2].
Methyl orsellinate (12.5-50 μg/mL; 24+ h) inhibits HSV-1-induced cytopathic effects in Vero cells with an EC50 of 13.50 μg/mL and a selectivity index of 5.55[2].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
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CAS No. 3187-58-4
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Appearance Solid
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Masse moléculaire 182.17
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Formule C9H10O4
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Color White to off-white
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SMILES
COC(C1=C(C=C(O)C=C1O)C)=O
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Structure Classification
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Initial Source
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Livraison
Room temperature in continental US; may vary elsewhere.
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Stockage
Powder -20°C 3 years In solvent -80°C 6 months -20°C 1 month
Solvant et solubilité
DMSO : 175 mg/mL (960.64 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Pureté et documentation
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Fiche technique (274 KB)
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SDS (394 KB)
- English - EN (394 KB)
- Français - FR (394 KB)
- Deutsch - DE (394 KB)
- Norwegian - NO (394 KB)
- Español - ES (394 KB)
- Swedish - SV (394 KB)
- Italian - IT (394 KB)
- Korean - KR (394 KB)
- Portuguese - PT (394 KB)
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Instruction de manipulation (2659 KB)
Références
[1]. Kim J, et al. Insecticidal and Enzyme Inhibitory Activities of Sparassol and Its Analogues against Drosophila suzukii. Journal of agricultural and food chemistry. 2016 Jul 13;64(27):5479-83. [Content Brief]
[2].
Bhat NB, et al. Molecular docking and dynamics supported investigation of antiviral activity of Lichen metabolites of Roccella montagnei: an in silico and in vitro study. J Biomol Struct Dyn. 2023;41(21):11484-11497.
[Content Brief]
[3]. Ingólfsdóttir K, et al. Effects of tenuiorin and methyl orsellinate from the lichen Peltigera leucophlebia on 5-/15-lipoxygenases and proliferation of malignant cell lines in vitro. Phytomedicine : international journal of phytotherapy and phytopharmacology. 2002 Oct;9(7):654-8. [Content Brief]
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO | 1 mM | 5.4894 mL | 27.4469 mL | 54.8938 mL | 137.2345 mL |
| 5 mM | 1.0979 mL | 5.4894 mL | 10.9788 mL | 27.4469 mL | |
| 10 mM | 0.5489 mL | 2.7447 mL | 5.4894 mL | 13.7234 mL | |
| 15 mM | 0.3660 mL | 1.8298 mL | 3.6596 mL | 9.1490 mL | |
| 20 mM | 0.2745 mL | 1.3723 mL | 2.7447 mL | 6.8617 mL | |
| 25 mM | 0.2196 mL | 1.0979 mL | 2.1958 mL | 5.4894 mL | |
| 30 mM | 0.1830 mL | 0.9149 mL | 1.8298 mL | 4.5745 mL | |
| 40 mM | 0.1372 mL | 0.6862 mL | 1.3723 mL | 3.4309 mL | |
| 50 mM | 0.1098 mL | 0.5489 mL | 1.0979 mL | 2.7447 mL | |
| 60 mM | 0.0915 mL | 0.4574 mL | 0.9149 mL | 2.2872 mL | |
| 80 mM | 0.0686 mL | 0.3431 mL | 0.6862 mL | 1.7154 mL | |
| 100 mM | 0.0549 mL | 0.2745 mL | 0.5489 mL | 1.3723 mL |
Methyl orsellinate Related Classifications
HY-N3270 Related Classifications
Powered by Bioz
- Methyl orsellinate
- 3187-58-4
- Lipoxygenase
- Glutathione S-transferase
- Cholinesterase (ChE)
- Insecticide
- HSV
- soybean 15-lipoxygenase
- PANC-1 pancreatic cancer cell line
- Drosophila suzukii
- glutathione S-transferase
- herpes simplex virus-1
- T-47D breast cancer cell line
- herpes simplex type-1 thymidine kinase
- acetylcholinesterase
- porcine leucocyte 5-lipoxygenase
- Vero cells
- Inhibitor
- inhibitor
- inhibit