Cat. No.: HY-N10902

Methyl pheophorbide a

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Methyl pheophorbide a is a natural product, one of the chlorophyll-a derivatives. Methyl pheophorbide a is a photosensitizer that produces singlet oxygen and reactive oxygen species (ROS) under light of specific wavelength, thereby leading to cell death.

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Pureté: 99.57%
CAS No.: 5594-30-9
Formule: C₃₆H₃₈N₄O₅
Masse moléculaire:606.71

Stockage:

Powder -20°C, 3 years ; In solvent -80°C, 6 months , -20°C, 1 month

Methyl pheophorbide a Chemical Structure

CAS No.: 5594-30-9

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Activité biologique
- Description
- Cellular Effect
- In Vitro
Chemical Information
Pureté et documentation
Références
Calculators
Help & FAQs
Classifications
Bioz

Activité biologique

Description

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Cellular Effect

Cell Line	Type	Value	Description	References
1A9	ED₅₀	0.26 μg/mL Compound: 5	Cytotoxicity against human 1A9 cells after 72 hrs by SRB assay Cytotoxicity against human 1A9 cells after 72 hrs by SRB assay	[PMID: 11473423]
A549	ED₅₀	0.83 μg/mL Compound: 5	Cytotoxicity against human A549 cells after 72 hrs by SRB assay Cytotoxicity against human A549 cells after 72 hrs by SRB assay	[PMID: 11473423]
Daudi	IC₅₀	25 μM Compound: 6, mPheo	Cytotoxicity against human Daudi cells under deem light after 96 hrs by MTT assay Cytotoxicity against human Daudi cells under deem light after 96 hrs by MTT assay	[PMID: 17993275]
HCT-8	ED₅₀	1 μg/mL Compound: 5	Cytotoxicity against human HCT8 cells after 72 hrs by SRB assay Cytotoxicity against human HCT8 cells after 72 hrs by SRB assay	[PMID: 11473423]
HeLa	IC₅₀	0.182 μM Compound: 7, MPa	Photosensitizing activity against human HeLa cells assessed as reduction in cell viability pre-incubated for 24 hrs followed by 15 mins exposure to 670 to 710 nm light at dose of 2.0 J/cm2 and measured 12 hrs after radiation by WST-8 assay Photosensitizing activity against human HeLa cells assessed as reduction in cell viability pre-incubated for 24 hrs followed by 15 mins exposure to 670 to 710 nm light at dose of 2.0 J/cm2 and measured 12 hrs after radiation by WST-8 assay	[PMID: 25797162]
HeLa	IC₅₀	25 μM Compound: 6, mPheo	Cytotoxicity against human HeLa cells under deem light after 96 hrs by MTT assay Cytotoxicity against human HeLa cells under deem light after 96 hrs by MTT assay	[PMID: 17993275]
K562	IC₅₀	>100 μM Compound: 6, mPheo	Cytotoxicity against human K562 cells under deem light after 96 hrs by MTT assay Cytotoxicity against human K562 cells under deem light after 96 hrs by MTT assay	[PMID: 17993275]
KB	ED₅₀	0.23 μg/mL Compound: 5	Cytotoxicity against human KB cells after 72 hrs by SRB assay Cytotoxicity against human KB cells after 72 hrs by SRB assay	[PMID: 11473423]
MCF7	ED₅₀	0.95 μg/mL Compound: 5	Cytotoxicity against human MCF7 cells after 72 hrs by SRB assay Cytotoxicity against human MCF7 cells after 72 hrs by SRB assay	[PMID: 11473423]
NCI-H69	IC₅₀	>100 μM Compound: 6, mPheo	Cytotoxicity against human H69 cells under deem light after 96 hrs by MTT assay Cytotoxicity against human H69 cells under deem light after 96 hrs by MTT assay	[PMID: 17993275]
Raji	IC₅₀	>100 μM Compound: 6, mPheo	Cytotoxicity against human Raji cells under deem light after 96 hrs by MTT assay Cytotoxicity against human Raji cells under deem light after 96 hrs by MTT assay	[PMID: 17993275]
SiHa	IC₅₀	>100 μM Compound: 6, mPheo	Cytotoxicity against human SIHA cells under deem light after 96 hrs by MTT assay Cytotoxicity against human SIHA cells under deem light after 96 hrs by MTT assay	[PMID: 17993275]
SK-MEL	ED₅₀	1.2 μg/mL Compound: 5	Cytotoxicity against human SK-MEL cells after 72 hrs by SRB assay Cytotoxicity against human SK-MEL cells after 72 hrs by SRB assay	[PMID: 11473423]

In Vitro

Methyl pheophorbide a (0.25-2 μg/mL, 4 h) reduces the cell viability of U937 and SK-HEP-1, activates caspase 3/7, causes the formation of apoptotic bodies and vesicle, and induces apoptosis^[3].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Cell Viability Assay^[3]

Cell Line:

U937 and SK-HEP-1
Concentration:

0.25-2 μg/mL
Incubation Time:

4 h
Result:

Inhibited cell viability under light.

Chemical Information

CAS No. 5594-30-9
Appearance Solid
Masse moléculaire 606.71
Formule C₃₆H₃₈N₄O₅
Color Brown to black
SMILES

COC([C@@H]1/C2=C([C@H]([C@@H]3C)CCC(OC)=O)/N=C3/C=C(C(C)=C/4C=C)\NC4=C/C5=N/C(C(CC)=C5C)=C\C6=C(C)C(C1=O)=C2N6)=O
Structure Classification
- Alkaloids
- Pyrrole Alkaloids
Initial Source
- Plants
- Compositae
Livraison

Room temperature in continental US; may vary elsewhere.

Stockage

Powder	-20°C	3 years
In solvent	-80°C	6 months
	-20°C	1 month

Pureté et documentation

Select Batch:

Pureté: 99.98%

Assay: 99.98%

ee.: 99.98%

Fiche technique (279 KB)
SDS (251 KB)
- English - EN (251 KB)
- Français - FR (251 KB)
- Deutsch - DE (251 KB)
- Norwegian - NO (251 KB)
- Español - ES (251 KB)
- Swedish - SV (251 KB)
- Italian - IT (251 KB)
- Korean - KR (251 KB)
- Portuguese - PT (251 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Instruction de manipulation (2659 KB)

Références

[1]. F.C. Pennington, et al. Preparation and Properties of Pyrochlorophyll a, Methyl Pyrochlorophyllide a, Pyropheophytin a, and Methyl Pyropheophorbide a Derived from Chlorophyll by Decarbomethoxylation. J. Am. Chem. Soc. 1964, 86, 7, 1418-1426.

[2]. ShinOgasawara, et al. C132-Methylation of methyl pheophorbide a and stereoselective preparation of methyl (132R)-methylpyropheophorbide a. Tetrahedron Letters, 2014, 3618-3621.

[3]. Ha J Y, et al. Isolation, identification, and apoptosis activity of the photosensitizer methyl pheophorbide A from Perilla frutescens leaves[J]. Applied Biological Chemistry, 2022, 65(1): 52.

Calculators

Calculateur de molarité

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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Methyl pheophorbide a

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Voir tous les produits spécifiques à Isoform Caspase

Activité biologique

Chemical Information

Pureté et documentation

Références

Calculators

Help & FAQs

Methyl pheophorbide a

Apoptosis Compound Library

Immunology/Inflammation Compound Library

Metabolism/Protease Compound Library

NF-κB Signaling Compound Library

Natural Product Library

Anti-Cancer Compound Library

Anti-Aging Compound Library

Traditional Chinese Medicine Active Compound Library

Alkaloids Library

Anti-Cancer Natural Product Library

Anti-inflammatory Traditional Chinese Medicine Active Compound Library

Plant-Sourced Natural Product Library

Highly Selective Activators Library

Cell Death Library

Bioactive Compound Library Max

MCE Bioactive Compound Library

Natural Product Library Plus

Natural Product and Natural Product-Like Compound Library

Bioactive Compound Library

Miao Ethnicity Medicine Compound Library

Tibetan Medicine Compound Library

Non-Alcoholic Fatty Liver Disease (NAFLD) Compound Library

High-Throughput Bioactive Compound Library

High-Throughput Natural Product Library

Lactylation Compound Library

Mass Spectrometry Natural Product Library

Voir tous les produits spécifiques à Isoform Caspase

Activité biologique

Chemical Information

Pureté et documentation

Références

Calculators

Help & FAQs

Methyl pheophorbide a Related Classifications

HY-N10902 Related Classifications