Preparation and in vitro biological evaluation of tetrapyrrole ethanolamide derivatives as potential anticancer agents

  • Bioorg Med Chem Lett. 2008 Jan 1;18(1):360-5. doi: 10.1016/j.bmcl.2007.10.069.
Denis Girard  1 ,  Glenn Weagle ,  Atul Gupta ,  Gervais Bérubé ,  Camille Chapados
Affiliations
  • 1. Département de Chimie-Biologie, Université du Québec à Trois-Rivières, Trois-Rivières, Que., Canada G9A 5H7.
PMID: 17993275 DOI: 10.1016/j.bmcl.2007.10.069
Abstract

Tetrapyrrole ethanolamide derivatives, 1 and 2, were prepared from hematoporphyrin IX (HPIX, 3) and methyl pheophorbide a (mPheo, 6). These were evaluated for their dual action as chemotherapeutics and photosensitizers in treatment of Cancer. The novel compounds showed significant in vitro Anticancer activity as measured in different cell lines using the MTT assay and photodynamic activity measured by erythrocytes' photohemolysis.