Nystatin A1
Nystatin A1 is a polyene macrolide antifungal antibiotic that can be isolated from Streptomyces noursei. Nystatin A1 binds to ergosterol on the fungal cell membrane, increasing the permeability of the cell membrane and causing leakage of cell contents, thereby inhibiting the growth and reproduction of fungi.
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- CAS No.: 34786-70-4
- Formule: C47H75NO17
- Masse moléculaire:926.09
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Stockage:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Activité biologique
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Chemical Information
- Pureté et documentation
- Références
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Activité biologique
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Cell Line
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Type | Value | Description | References |
|---|---|---|---|---|
| HEp-2 | CC50 |
13.6 μg/mL
Compound: Nystatin
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Cytotoxicity against human HEp-2 cells assessed as reduction in cell viability incubated for 40 to 60 mins by resazurin dye based assay
Cytotoxicity against human HEp-2 cells assessed as reduction in cell viability incubated for 40 to 60 mins by resazurin dye based assay
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[PMID: 35178173] |
| HEp-2 | CC50 |
78 units/mg
Compound: Nystatin
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Cytotoxicity against human HEp-2 cells assessed as reduction in cell viability incubated for 40 to 60 mins by resazurin dye based assay
Cytotoxicity against human HEp-2 cells assessed as reduction in cell viability incubated for 40 to 60 mins by resazurin dye based assay
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[PMID: 35178173] |
| WI-38 | CC50 |
48.56 μM
Compound: Nystatin
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Cytotoxicity against human WI38 cells assessed as reduction in cellular DNA level preincubated for 2 hrs before viral infection measured after 7 days by real time PCR assay
Cytotoxicity against human WI38 cells assessed as reduction in cellular DNA level preincubated for 2 hrs before viral infection measured after 7 days by real time PCR assay
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[PMID: 17893158] |
| WI-38 | EC50 |
9.81 μM
Compound: Nystatin
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Antiviral activity against BKV Gardner ATCC VR837 infected in human WI38 cells assessed as reduction in viral DNA level preincubated for 2 hrs before viral infection measured after 7 days by real time PCR assay
Antiviral activity against BKV Gardner ATCC VR837 infected in human WI38 cells assessed as reduction in viral DNA level preincubated for 2 hrs before viral infection measured after 7 days by real time PCR assay
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[PMID: 17893158] |
Chemical Information
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CAS No. 34786-70-4
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Masse moléculaire 926.09
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Formule C47H75NO17
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SMILES
O=C([C@H]1[C@]2([H])C[C@@H](O[C@H]3[C@@H](O)[C@@H](N)[C@H](O)[C@@H](C)O3)/C=C/C=C/C=C/C=C/CC/C=C/C=C/[C@H](C)[C@@H](O)[C@@H](C)[C@H](C)OC(C[C@H](O)C[C@H](O)C[C@H](O)CC[C@@H](O)[C@H](O)C[C@](O2)(O)C[C@@H]1O)=O)O
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Livraison
Room temperature in continental US; may vary elsewhere.
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Stockage
Please store the product under the recommended conditions in the Certificate of Analysis.
Pureté et documentation
Références
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Nystatin A1 Related Classifications
HY-159666 Related Classifications
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