Psicofuranine
Based on 1 Customer Validation
Psicofuramine a nucleoside antibiotic and has the inhibition of xanthosine 5'-phosphate aminase. Psicofuranine also specifically inhibits GMP synthase, and interrupts parasite growth. Psicofuranine exhibits a dose-dependent inhibition of P. falciparum growth.
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- Pureté: 98.0%
- CAS No.: 1874-54-0
- Formule: C11H15N5O5
- Masse moléculaire:297.27
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Stockage:Powder -20°C, 3 years ; In solvent -80°C, 6 months , -20°C, 1 month
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Activité biologique
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Chemical Information
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Solvant et solubilité
- Pureté et documentation
- Références
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Help & FAQs
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Activité biologique
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Plasmodium |
Psicofuranine specifically inhibits bacterial GMP synthase as demonstrated by isolation of Psicofuranine-resistant Escherichia coli mutants with mutations in the gene encoding GMP synthase and inhibition of bacterial growth. Psicofuranine exhibits a dose-dependent inhibition of P. falciparum growth with an IC50 of 0.3 mM. The Psicofuranine inhibitory concentration is similar to that of E. coli[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
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CAS No. 1874-54-0
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Appearance Solid
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Masse moléculaire 297.27
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Formule C11H15N5O5
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Color White to off-white
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SMILES
OC[C@@H]1[C@H]([C@H]([C@@](CO)(O1)N2C=NC3=C2N=CN=C3N)O)O
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Livraison
Room temperature in continental US; may vary elsewhere.
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Stockage
Powder -20°C 3 years In solvent -80°C 6 months -20°C 1 month
Solvant et solubilité
DMSO : 50 mg/mL (168.20 mM; Need ultrasonic and warming; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Pureté et documentation
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Fiche technique (290 KB)
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SDS (393 KB)
- English - EN (393 KB)
- Français - FR (393 KB)
- Deutsch - DE (393 KB)
- Norwegian - NO (393 KB)
- Español - ES (393 KB)
- Swedish - SV (393 KB)
- Italian - IT (393 KB)
- Korean - KR (393 KB)
- Portuguese - PT (393 KB)
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Instruction de manipulation (2659 KB)
Références
[1]. cConkey GA. Plasmodium falciparum: isolation and characterisation of a gene encoding protozoan GMP synthase. Exp Parasitol. 2000 Jan;94(1):23-32. [Content Brief]
[2]. UDAKA S, et al. INHIBITION OF PARENTAL AND MUTANT XANTHOSINE 5'-PHOSPHATE AMINASES BY PSICOFURANINE. J Biol Chem. 1963 Aug;238:2797-803. [Content Brief]
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO | 1 mM | 3.3639 mL | 16.8197 mL | 33.6395 mL | 84.0986 mL |
| 5 mM | 0.6728 mL | 3.3639 mL | 6.7279 mL | 16.8197 mL | |
| 10 mM | 0.3364 mL | 1.6820 mL | 3.3639 mL | 8.4099 mL | |
| 15 mM | 0.2243 mL | 1.1213 mL | 2.2426 mL | 5.6066 mL | |
| 20 mM | 0.1682 mL | 0.8410 mL | 1.6820 mL | 4.2049 mL | |
| 25 mM | 0.1346 mL | 0.6728 mL | 1.3456 mL | 3.3639 mL | |
| 30 mM | 0.1121 mL | 0.5607 mL | 1.1213 mL | 2.8033 mL | |
| 40 mM | 0.0841 mL | 0.4205 mL | 0.8410 mL | 2.1025 mL | |
| 50 mM | 0.0673 mL | 0.3364 mL | 0.6728 mL | 1.6820 mL | |
| 60 mM | 0.0561 mL | 0.2803 mL | 0.5607 mL | 1.4016 mL | |
| 80 mM | 0.0420 mL | 0.2102 mL | 0.4205 mL | 1.0512 mL | |
| 100 mM | 0.0336 mL | 0.1682 mL | 0.3364 mL | 0.8410 mL |
Psicofuranine Related Classifications
HY-119819 Related Classifications
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