Ser@TPP@CUR
Ser@TPP@CUR is a Curcumin (HY-N0005) derivative. Ser@TPP@CUR effectively ameliorates injured renal tubular epithelial cells and improves renal functions of acute kidney injury (AKI) mice. Ser@TPP@CUR can be used for the research of AKI .
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- CAS No.: 3032193-12-4
- Formule: C47H47BrNO9P
- Masse moléculaire:880.76
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Stockage:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Activité biologique
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Chemical Information
- Pureté et documentation
- Références
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Help & FAQs
Activité biologique
Description
In Vitro
Ser@TPP@CUR (7.16 μg/mL; 24 h) effectively reduces ROS level in inflammatory HK-2 cells[1]. Ser@TPP@CUR (3 μg/mL; 24 h) effects cell viability and inhibits expression levels of cytosolic cytochrome c, cleaved caspase-3, and cleaved caspase-9 of LPS-induced HK-2 cells[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Cell Line:LPS-induced HK-2 cell lines
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Concentration:3 μg/mL
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Incubation Time:24 hours
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Result:Significantly improved cell viability of LPS-induced HK-2 cells.
In Vivo
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Animal Model:AKI mice[1]
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Dosage:4 mg/kg
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Administration:Intravenous injection; 4 mg/kg once
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Result:Showed a better distributionin in renal tissues than CUR at 2 hours after injection and restored renal function of AKI mice by alleviated Scr and BUN levels.
Chemical Information
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CAS No. 3032193-12-4
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Masse moléculaire 880.76
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Formule C47H47BrNO9P
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SMILES
COC(C=C1/C=C/C(CC(/C=C/C2=CC(OC)=C(OC(CCCC[P+](C3=CC=CC=C3)(C4=CC=CC=C4)C5=CC=CC=C5)=O)C=C2)=O)=O)=C(C=C1)OC([C@@H](N)CO)=O.[Br-]
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Livraison
Room temperature in continental US; may vary elsewhere.
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Stockage
Please store the product under the recommended conditions in the Certificate of Analysis.
Pureté et documentation
Références
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Ser@TPP@CUR Related Classifications
HY-151342 Related Classifications
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