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VTP50469 mesylate

(Synonyms: SNDX-50469 mesylate)
13 Cited Publications
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Based on 13 publication(s) in Google Scholar

VTP50469 mesylate is a potent, and selective Menin-MLL1 inhibitor that effectively targets MLL-rearranged and NPM1c+ leukemia. VTP50469 mesylate selectively kills cell lines with MLL rearrangements and NPM1c+ mutations. VTP50469 mesylate displaces Menin from protein complexes and inhibits MLL's chromatin occupancy at specific genes, leading to significant changes in gene expression, differentiation, and apoptosis. VTP50469 demonstrates dramatic reductions in leukemia burden in patient-derived xenograft models of MLL-r acute myeloid leukemia and MLL-r acute lymphoblastic leukemia, with some mice remaining disease-free for over a year post-treatment.

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  • CAS No.: 2169919-27-9
  • Formule: C34H55FN6O10S3
  • Masse moléculaire:823.03
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  • VTP50469 mesylate Chemical Structure
    VTP50469 mesylate Chemical Structure
  • Experimental Validation Results for VTP50469 mesylate
  • Experimental Validation Results for VTP50469 mesylate
  • Experimental Validation Results for VTP50469 mesylate
  • Experimental Validation Results for VTP50469 mesylate
  • Experimental Validation Results for VTP50469 mesylate
CAS No.: 2169919-27-9
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  • VTP50469 mesylate Chemical Structure
    VTP50469 mesylate Chemical Structure
    1/16
  • 1/16

    VTP50469 mesylate purchased from MedChemExpress. Usage Cited in: Nat Commun. 2025 Mar 18;16(1):2641. [Abstract]

    Customer Validation
     Relative viability of MOLM-13 cells following treatment with different concentrations of VTP50469 (3.91-1000 nM) over 2-7 days.

  • 1/16

    VTP50469 mesylate purchased from MedChemExpress. Usage Cited in: Nat Commun. 2025 Mar 18;16(1):2641. [Abstract]

    Customer Validation
     Relative viability of human AML cell lines upon treatment with different concentrations of VTP50469 (3.91-1000 nM) over 5 days.

  • 1/16

    VTP50469 mesylate purchased from MedChemExpress. Usage Cited in: Leukemia. 2025 Jan;39(1):75-86. [Abstract]

    Customer Validation
     NPM1::CCDC28A cells and mouse cKit+ bone marrow cells were incubated with selinexor or VTP50469 (0, 0.1, 0.3, 1, 3, 10, and 30 μM) at the indicated concentration for 72 h. Cell viability was assessed using the Cell Counting Kit-8.

  • 1/16

    VTP50469 mesylate purchased from MedChemExpress. Usage Cited in: Nat Cell Biol. 2023 Sep;25(9):1346-1358. [Abstract]

    Customer Validation
     Immunoblot analysis of 1014 Kdm6a isogenic cells treated with inhibitors that block the function of epigenetic modifiers that normally maintain gene expression including VTP50469 (500 nM), EPZ-5676 (1 μM), PF-9363 (100 nM), JQAD1 or DMSO for 6 days.

  • 1/16

    VTP50469 mesylate purchased from MedChemExpress. Usage Cited in: Blood Cancer J. 2022 Jan 11;12(1):5. [Abstract]

    Customer Validation
     A, B MOLM13 and OCI-AML3 cells were treated with the indicated concentrations of VTP50469 (SNDX-50469; 0, 0.25, 1 μM) for 48 h. Following this, total cell lysates were prepared and immunoblot analyses were conducted. The expression levels of β-Actin in the lysates served as the loading control.

  • VTP50469 mesylate