152-47-6
Chemical Structure
Sulfalene
Synonym(s): Sulfametopyrazine; AS-18908
- CAS No.: 152-47-6
- Formula:C11H12N4O3S
- Molecular Weight:280.30
IUPAC Name: 4-amino-N-(3-methoxypyrazin-2-yl)benzenesulfonamide
InChIKey: KXRZBTAEDBELFD-UHFFFAOYSA-N
SMILES: O=S(C1=CC=C(N)C=C1)(NC2=NC=CN=C2OC)=O
Biological Activity: Sulfalene (Sulfametopyrazine) is an orally active antimalarial agent. Sulfalene competes with para-aminobenzoic acid in plasmodial and bacterial folic acid synthesis pathways. Sulfalene reduces trachoma-associated pathological changes. Sulfalene can be used for the research of acute falciparum malaria, Schistosoma mansoni infection, trachoma, chronic bronchitis, and bacteriuria in pregnancy[1][2][3][4][5].
| Cat. No. | Product Name | Purity | Description | Pricing | |||||||||||||||||||
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Sulfalene | 99.73% | Sulfalene (Sulfametopyrazine) is an orally active antimalarial agent. Sulfalene competes with para-aminobenzoic acid in plasmodial and bacterial folic acid synthesis pathways. Sulfalene reduces trachoma-associated pathological changes. Sulfalene can be used for the research of acute falciparum malaria, Schistosoma mansoni infection, trachoma, chronic bronchitis, and bacteriuria in pregnancy. | ||||||||||||||||||||
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Sulfalene (Standard) | ≥98% | Sulfalene (Standard) is the analytical standard of Sulfalene. This product is intended for research and analytical applications. Sulfalene (Sulfametopyrazine; AS-18908) is an orally active antimalarial agent. Sulfalene competes for para-aminobenzoic acid binding in plasmodial folic acid synthesis. Sulfalene, combined with Trimethoprim (HY-B0510), clears parasites, resolves fever, and resists induced resistance against drug-sensitive and drug-resistant Plasmodium falciparum. Sulfalene can be used for the research of acute falciparum malaria and Schistosoma mansoni infection. | ||||||||||||||||||||
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Sulfalene-13C6 | 99.0% | Sulfalene-13C6 is the 13C6 labeled Sulfalene. Sulfalene (Sulfametopyrazine) is an antimalarial agent. Sulfalene is also a long-acting sulfonamide antibacterial. | ||||||||||||||||||||
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References
- [1]. Martin DC, et al. Treatment of acute falciparum malaria with sulfalene and trimethoprim. JAMA. 1968 Feb 12;203(7):476-80. [Content Brief]
- [2]. Obonyo CO, et al. Efficacy of artesunate with sulfalene plus pyrimethamine versus praziquantel for treatment of Schistosoma mansoni in Kenyan children: an open-label randomised controlled trial. Lancet Infect Dis. 2010;10(9):603-611. [Content Brief]
- [3]. Bietti GB, et al. Further contributions to the intermittent therapy of trachoma with new long-acting sulfonamides. Am J Ophthalmol. 1967 May;63(5):Suppl:1569-73. [Content Brief]
- [4]. Darke CS, et al. Sulfametopyrazine in the prophylaxis of exacerbations of chronic bronchitis. Br J Dis Chest. 1972 Oct;66(4):276-83. [Content Brief]
- [5]. Reeves DS. Laboratory and clinical studies with sulfametopyrazine as a treatment for bacteriuria in pregnancy. J Antimicrob Chemother. 1975 Jun;1(2):171-86. [Content Brief]
