852-19-7
Chemical Structure
Sulfamethylphenazole
Synonym(s): Sulfapyrazole; Vesulong
- CAS No.: 852-19-7
- Formula:C16H16N4O2S
- Molecular Weight:328.39
IUPAC Name: 4-amino-N-(3-methyl-1-phenyl-1H-pyrazol-5-yl)benzenesulfonamide
InChIKey: MTERSQYMYBGZTP-UHFFFAOYSA-N
SMILES: O=S(NC1=CC(C)=NN1C2=CC=CC=C2)(C3=CC=C(N)C=C3)=O
Biological Activity: Sulfamethylphenazole (Sulfapyrazole; Vesulong) is a long-acting sulfonamide antibacterial agent. Sulfamethylphenazole maintains effective chemotherapeutic blood concentrations through the slow release of free sulfonamide from a protein-binding reservoir and can be used in combination with antibiotics such as Terramycin for bovine hemorrhagic septicemia. Sulfamethylphenazole exhibits moderate antimycobacterial activity against Mycobacterium tuberculosis H37Rv (MIC = 15.38 μg/mL) and inhibitory activity against CYP 2C9. Sulfamethylphenazole can be used in studies related to tuberculosis and hemorrhagic septicemia[1][2][3].
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Sulfamethylphenazole | Sulfamethylphenazole (Sulfapyrazole; Vesulong) is a long-acting sulfonamide antibacterial agent. Sulfamethylphenazole maintains effective chemotherapeutic blood concentrations through the slow release of free sulfonamide from a protein-binding reservoir and can be used in combination with antibiotics such as Terramycin for bovine hemorrhagic septicemia. Sulfamethylphenazole exhibits moderate antimycobacterial activity against Mycobacterium tuberculosis H37Rv (MIC = 15.38 μg/mL) and inhibitory activity against CYP 2C9. Sulfamethylphenazole can be used in studies related to tuberculosis and hemorrhagic septicemia. | |||||||||||||||||||||
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References
- [1]. Chen H, et al. The optimization and characterization of functionalized sulfonamides derived from sulfaphenazole against Mycobacterium tuberculosis with reduced CYP 2C9 inhibition. Bioorganic & medicinal chemistry letters. 2021 May 15;40:127924. [Content Brief]
- [2]. Weiser M, et al. Über die Dosierung von Vesulong® bei Rindern[J]. Zentralblatt für Veterinärmedizin Reihe A, 1971, 18(6): 536-539.
- [3]. Sheikh MA, Anzam M, Shakoori AR. Observations on haemorrhagic septicaemia in Pakistan livestock. Zentralbl Veterinarmed B. 1996 Jul;43(5):293-304. [Content Brief]
