c-Kit
SCFR; CD117
c-Kit (Mast/stem cell growth factor receptor, SCFR or CD117) is a proteinthat in humans is encoded by the KIT gene. c-Kit (CD117) is an important cell surface marker used to identify certain types of hematopoietic(blood) progenitors in the bone marrow. c-Kit is a cytokine receptor expressed on the surface of hematopoietic stem cells as well as other cell types. Altered forms of this receptor may be associated with some types of cancer. c-Kit is a receptor tyrosine kinase type III, which binds to stem cell factor. When c-Kit binds to stem cell factor (SCF) it forms adimer that activates its intrinsic tyrosine kinase activity, that in turn phosphorylates and activates signal transduction molecules that propagate the signal in the cell. Signalling through c-Kit plays a role in cell survival, proliferation, and differentiation.
All Product Categories
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c-Kit Verwandte Produkte (206)
Verwandte Produkte (206)
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Recombinant Proteins (20)
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Antibodies (3)
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c-Kit-IN-11
0 ImagesArt. -Nr.: HY-177286CAS. Nr.: 1185279-55-3c-Kit-IN-11 (Compound A7) is a c-Kit inhibitor with an IC50 of 76 nM for Mo7e cells. c-Kit-IN-11 can be used for inflammatory like asthma and malignant cancers research.
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Anti-inflammatory agent 117
0 ImagesArt. -Nr.: HY-184327Anti-inflammatory agent 117 is an orally active anti-inflammatory agent and c-Kit kinase inhibitor with an IC50 of 15.2 μM. Anti-inflammatory agent 117 blocks the NF-κB signaling pathway and inhibits the release of IL-6. Anti-inflammatory agent 117 exhibits anti-inflammatory effects in mouse models of acute lung injury, sepsis and ulcerative colitis. Anti-inflammatory agent 117 can be used in research related to acute lung injury, sepsis and ulcerative colitis.
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Antitumor agent-70
0 ImagesArt. -Nr.: HY-149019CAS. Nr.: 2454133-88-9
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GW694590A
0 ImagesArt. -Nr.: HY-160689CAS. Nr.: 948313-24-4Synonyms: UNC10112731GW694590A (UNC10112731) is a MYC protein stabilizer that increases endogenous MYC protein levels. GW694590A also targets receptor tyrosine kinases, inhibiting DDR2, KIT and PDGFRα by 81% at 1 μM. , 68% and 67%. GW694590A is a protein kinase inhibitor across ATP-dependent and -independent luciferases with potential effects on the Fluc reporter gene.
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KIT Recombinant Human Active Protein Kinase
0 ImagesArt. -Nr.: HY-E70840Kit is a type III receptor protein-tyrosine kinase. Signaling by stem cell factor and Kit, its receptor, play important roles in gametogenesis, hematopoiesis, mast cell development and function, and melanogenesis. KIT Recombinant Human Active Protein Kinase is a recombinant KIT protein that can be used to study KIT-related functions.
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Multi-kinase-IN-6
0 ImagesArt. -Nr.: HY-156470CAS. Nr.: 3009081-73-3Multi-kinase-IN-6 (compound 10e) is a multikinase inhibitor that shows good enzyme inhibitory activity against TrkA, ALK2, c-KIT, EGFR, PIM1, CK2α, CHK1, and CDK2. Multi-kinase-IN-6 reveals antiproliferative activity against MCF7, HCT116 and EKVX with IC50 values of 3.36 μM, 1.40 μM and 3.49 μM, respectively. Multi-kinase-IN-6 shows cell cycle arrest at the G1/S phase and G1 phase in MCF7 and HCT116 cells with good apoptotic effect.
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Multi-kinase-IN-5
0 ImagesArt. -Nr.: HY-149415Multi-kinase-IN-5 (compound 15c) is a promising multi-kinase inhibitory agent. Multi-kinase-IN-5 inhibits a panel of protein kinases (RET, KIT, cMet, VEGFR1,2, FGFR1, PDGFR and BRAF), showing % inhibition of 74%, 31%, 62%, 40%, 73%, 74%, 59%, and 69%, respectively, and IC50 of 1.287, 0.117 and 1.185 μM against FGFR1, VEGFR, and RET kinases, respectively.
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c-Kit-IN-8
0 ImagesArt. -Nr.: HY-168581CAS. Nr.: 2941024-89-9
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KIT V559D/T670I Recombinant Human Active Protein Kinase
0 ImagesArt. -Nr.: HY-E70739KIT (CD117) is an important cell surface marker used to identify certain types of hematopoietic(blood) progenitors in the bone marrow. KIT is a cytokine receptor expressed on the surface of hematopoietic stem cells as well as other cell types. Altered forms of this receptor may be associated with some types of cancer. KIT V559D/T670I is a mutant of KIT. KIT V559D/T670I Recombinant Human Active Protein Kinase is a recombinant KIT V559D/T670I protein that can be used to study KIT V559D/T670I-related functions.
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VEGFR2-IN-84
0 ImagesArt. -Nr.: HY-182354CAS. Nr.: 861877-12-5VEGFR2-IN-84 is an orally active, multi-targeted tyrosine kinase inhibitor based on a naphthalene ring scaffold. VEGFR2-IN-84 inhibits VEGFR2 with sub-nanomolar affinity and broadly targets kinases including Kit, FGFR, PDGFR, and Ret. By competitively binding to the ATP-binding pocket, VEGFR2-IN-84 blocks the phosphorylation of VEGFR2 and its downstream AKT/ERK signaling pathway, thereby significantly inhibiting endothelial cell proliferation, migration, and tumor angiogenesis. VEGFR2-IN-84 exhibits broad-spectrum antiproliferative activity against various solid tumors such as liver cancer, lung cancer, and renal cancer, shows weak toxicity to normal cells, and has superior potency to Lenvatinib (HY-10981). VEGFR2-IN-84 possesses favorable pharmacokinetic properties and high safety (LD50>2000 mg/kg), and can be used in related studies of various malignant tumors.
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c-Kit-IN-10
0 ImagesArt. -Nr.: HY-177287CAS. Nr.: 1123512-36-6c-Kit-IN-10 (Compound 1) is a c-Kit inhibitor. c-Kit-IN-10 can be used for inflammatory like asthma and malignant cancers research.
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Tafetinib analogue 1
0 ImagesArt. -Nr.: HY-114588CAS. Nr.: 1032265-67-0Synonyms: SIM010603 analogue 1Tafetinib (SIM010603) analogue 1 is an analog of the tyrosine kinase receptor inhibitor Tafetinib (SIM010603)..
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CD117/c-Kit aptamer sodium
0 ImagesArt. -Nr.: HY-177821CD117/c-Kit aptamer sodium is a single-strand DNA aptamer specific for the biomarker CD117, which is highly expressed on acute myeloid leukemia (AML) cells.
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KIT V654A Recombinant Human Active Protein Kinase
0 ImagesArt. -Nr.: HY-E70742KIT (CD117) is an important cell surface marker used to identify certain types of hematopoietic(blood) progenitors in the bone marrow. KIT is a cytokine receptor expressed on the surface of hematopoietic stem cells as well as other cell types. Altered forms of this receptor may be associated with some types of cancer. KIT V654A is a mutant of KIT. KIT V654A Recombinant Human Active Protein Kinase is a recombinant KIT V654A protein that can be used to study KIT V654A-related functions.
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c-Kit-IN-9
0 ImagesArt. -Nr.: HY-170228Kit-IN-9 (Compound D9) is an inhibitor of c-Kit. c-Kit-IN-9 inhibits the inflammatory responses in J774A.1, RAW264.7, MPMs cells and lung tissues by blocking the activation of the NF-κB pathway induced by LPS (HY-D1056). Meanwhile, c-Kit-IN-9 exhibits good anti-inflammatory activities in acute lung injury and sepsis mouse models. c-Kit-IN-9 can be used in the research of acute lung injury and related inflammatory diseases.
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IHMT-TRK-284
0 ImagesArt. -Nr.: HY-146697CAS. Nr.: 2416844-79-4
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AP23464
0 ImagesArt. -Nr.: HY-10638CAS. Nr.: 845895-51-4AP23464 is an ATP-based inhibitor for Kit, that inhibits the phosphorylation of Kit wildtype and mutants, with IC50 of 5-85 nM. AP23464 inhibits the proliferation of Kit mutated cells (IC50 is 3-20 nM), arrests the cell cycle at G0/G1 phase, and induces apoptosis in Kit mutated cells.
