845895-51-4
845895-51-4
Chemical Structure
AP23464
- CAS 番号: 845895-51-4
- Formula:C26H30N5O2P
- Molecular Weight:475.52
IUPAC Name: (4-((2-cyclopentyl-9-(3-hydroxyphenethyl)-9H-purin-6-yl)amino)phenyl)dimethylphosphine oxide
InChIKey: VVOYROSONSLQQK-UHFFFAOYSA-N
SMILES: O=P(C)(C)C1=CC=C(NC2=NC(C3CCCC3)=NC4=C2N=CN4CCC5=CC(O)=CC=C5)C=C1
Biological Activity: AP23464 is an ATP-based inhibitor for Kit, that inhibits the phosphorylation of Kit wildtype and mutants, with IC50 of 5-85 nM. AP23464 inhibits the proliferation of Kit mutated cells (IC50 is 3-20 nM), arrests the cell cycle at G0/G1 phase, and induces apoptosis in Kit mutated cells[1].
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AP23464 | AP23464 is an ATP-based inhibitor for Kit, that inhibits the phosphorylation of Kit wildtype and mutants, with IC50 of 5-85 nM. AP23464 inhibits the proliferation of Kit mutated cells (IC50 is 3-20 nM), arrests the cell cycle at G0/G1 phase, and induces apoptosis in Kit mutated cells. | |||||||||||||||||||||
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