c-Kit
SCFR; CD117
c-Kit (Mast/stem cell growth factor receptor, SCFR or CD117) is a proteinthat in humans is encoded by the KIT gene. c-Kit (CD117) is an important cell surface marker used to identify certain types of hematopoietic(blood) progenitors in the bone marrow. c-Kit is a cytokine receptor expressed on the surface of hematopoietic stem cells as well as other cell types. Altered forms of this receptor may be associated with some types of cancer. c-Kit is a receptor tyrosine kinase type III, which binds to stem cell factor. When c-Kit binds to stem cell factor (SCF) it forms adimer that activates its intrinsic tyrosine kinase activity, that in turn phosphorylates and activates signal transduction molecules that propagate the signal in the cell. Signalling through c-Kit plays a role in cell survival, proliferation, and differentiation.
All Product Categories
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c-Kit Related Products (212)
Related Products (212)
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Recombinant Proteins (20)
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Antibodies (3)
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c-Kit-IN-7
0 ImagesCat. No.: HY-168580CAS No.: 2941026-35-1
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c-Met-IN-14
0 ImagesCat. No.: HY-150582CAS No.: 2443380-34-3c-Met-IN-14 (compound 26af) is a selective inhibitor of c-Met kinase from N-sulfonylamidine-based derivatives, with an IC50 value of 2.89 nM. c-Met-IN-14 shows anticancer activity by blocking phosphorylation of c-Met, and arrests cell cycle at G2/M phase. c-Met-IN-14 induces apoptosis of A549 cells in a dose-dependent manner.
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Dovitinib-d8
0 ImagesCat. No.: HY-50905SCAS No.: 1246819-84-0
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Pimicotinib hydrochloride
0 ImagesCat. No.: HY-153920ACAS No.: 2866305-19-1Synonyms: ABSK021 hydrochloridePimicotinib (ABSK021) hydrochloride is a selective and orally active CSF1R inhibitor with an IC50 value of 19.48 nM (determined by inhibiting ADP production). Pimicotinib hydrochloride exhibits anti-tumor activity.
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AK177
0 ImagesCat. No.: HY-181886AK177 is an allosteric activator of IRE1α ribonuclease, with values of 480 nM and 180 nM against non-phosphorylated and phosphorylated IRE1α, respectively. AK177 promotes IRE1α-mediated cleavage of XBP1 mRNA probe in a concentration-dependent manner and binds stably to its kinase domain. However, AK177 shows poor kinase selectivity, and due to poor membrane permeability at the cellular level, it induces no significant downstream pathway activation or antiproliferative activity.
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Kit-IN-1
0 ImagesCat. No.: HY-187462CAS No.: 3080682-21-6Kit-IN-1 is a kinome-selective and orally active KIT inhibitor with a human IC50 value of 2.8 nM. Kit-IN-1 binds to KIT in an allosteric mode, stabilizes the inactive DFG-out conformation of KIT, and blocks the stem cell factor (SCF)-mediated KIT phosphorylation signaling pathway. Kit-IN-1 inhibits SCF-induced ear swelling in rats and prevents increased vascular permeability. Kit-IN-1 can be used in studies related to mast cell-driven chronic inflammation.
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Regorafenib monohydrate (Standard)
0 ImagesSynonyms: BAY 73-4506 monohydrate (Standard)Regorafenib (monohydrate) (Standard) is the analytical standard of Regorafenib (monohydrate). This product is intended for research and analytical applications. Regorafenib (BAY 73-4506) monohydrate is an orally active and potent multi-targeted receptor tyrosine kinase inhibitor, with IC50 values of 13/4.2/46, 22, 7, 1.5 and 2.5 nM for VEGFR1/2/3, PDGFRβ, Kit, RET and Raf-1, respectively. Regorafenib monohydrate shows very robust antitumor and antiangiogenic activity.
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Kit-IN-2
0 ImagesCat. No.: HY-189056CAS No.: 3080682-14-7Kit-IN-2 is an orally active and highly selective KIT inhibitor. Kit-IN-2 stabilizes the inactive (DFG-out) conformation of KIT. Kit-IN-2 inhibits mast cell-mediated inflammatory responses by blocking stem cell factor-induced ear swelling and vascular permeability in rats. Kit-IN-2 exhibits favorable pharmacokinetic properties in rats. Kit-IN-2 can be used for studies related to acute allergy.
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PLX647 dihydrochloride
0 ImagesCat. No.: HY-13838ACAS No.: 1779796-38-1PLX647 dihydrochloride is an orally active, highly specific dual FMS and KIT kinase inhibitor, with IC50s of 28 and 16 nM, reapectively. PLX647 dihydrochloride shows selectivity for FMS and KIT over a panel of 400 kinases at a concentration of 1 μM except FLT3 and KDR (IC50s=91 and 130 nM, respectively).
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GW632046X
0 ImagesCat. No.: HY-160690CAS No.: 681002-67-5GW632046X is a Fluc (Firefly luciferase) inhibitor with an IC50 value of 0.58 µM.
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c-Kit-IN-14
0 ImagesCat. No.: HY-180653CAS No.: 3041025-49-1
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Midostaurin-13C6
0 ImagesCat. No.: HY-W751179Synonyms: PKC412-13C6; CGP 41251-13C6Midostaurin-13C6 (PKC412-13C6) is the 13C-labeled Midostaurin (HY-10230). Midostaurin (PKC412; CGP 41251) is an orally active, reversible multi-targeted protein kinase inhibitor. Midostaurin inhibits PKCα/β/γ, Syk, Flk-1, Akt, PKA, c-Kit, c-Fgr, c-Src, FLT3, PDFRβ and VEGFR1/2 with IC50s ranging from 22-500 nM. Midostaurin also upregulates endothelial nitric oxide synthase (eNOS) gene expression. Midostaurin shows powerful anticancer effects.
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BLU-654
0 ImagesCat. No.: HY-182043CAS No.: 2999638-62-7BLU-654 is an orally active antineoplastic agent and KIT inhibitor. BLU-654 is a highly selective inhibitor targeting wild-type KIT, PDGFRβ, and KITV654A over most other kinases in the kinome. BLU-654 exerts sustained antineoplastic activity in KITV654A cell-derived xenograft mouse models. BLU-654 can be used in research related to Imatinib (HY-15463)-resistant gastrointestinal stromal tumors.
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KIT V559D Recombinant Human Active Protein Kinase
0 ImagesCat. No.: HY-E70738KIT (CD117) is an important cell surface marker used to identify certain types of hematopoietic(blood) progenitors in the bone marrow. KIT is a cytokine receptor expressed on the surface of hematopoietic stem cells as well as other cell types. Altered forms of this receptor may be associated with some types of cancer. KIT V559D is a mutant of KIT. KIT V559D Recombinant Human Active Protein Kinase is a recombinant KIT V559D protein that can be used to study KIT V559D-related functions.
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KBP-7018 hydrochloride
0 ImagesCat. No.: HY-117873ACAS No.: 1613437-67-4KBP-7018 hydrochloride is an orally active, tyrosine kinase-selective multi-kinase inhibitor with an IC50 value of 10 nM against c-KIT, 7.6 nM against RET, and 25 nM against human PDGFR. KBP-7018 hydrochloride improves survival rates in a mouse model of pulmonary fibrosis. KBP-7018 hydrochloride can be used in research related to idiopathic pulmonary fibrosis.
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KIT V560G Recombinant Human Active Protein Kinase
0 ImagesCat. No.: HY-E70741KIT (CD117) is an important cell surface marker used to identify certain types of hematopoietic(blood) progenitors in the bone marrow. KIT is a cytokine receptor expressed on the surface of hematopoietic stem cells as well as other cell types. Altered forms of this receptor may be associated with some types of cancer. KIT V560G is a mutant of KIT. KIT V560G Recombinant Human Active Protein Kinase is a recombinant KIT V560G protein that can be used to study KIT V560G-related functions.
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Toceranib-d8
0 ImagesToceranib-d8 is the deuterium labeled Toceranib. Toceranib (SU11654) is an orally active receptor tyrosine kinase (RTK) inhibitor, and it potently inhibits PDGFR, VEGFR, and Kit with Kis of 5 and 6 nM for PDGFRβ and Flk-1/KDR, respectively. Toceranib (SU11654) has antitumor and antiangiogenic activity, and used in the treatment of canine mast cell tumors.
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APcK110
0 ImagesCat. No.: HY-110071CAS No.: 1001083-74-4APcK110 is a potent Kit inhibitor that can be used for the research of acute myeloid leukemia (AML). APcK110 induces AML cell apoptosis.
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KIT D816V Recombinant Human Active Protein Kinase
0 ImagesCat. No.: HY-E70736KIT (CD117) is an important cell surface marker used to identify certain types of hematopoietic(blood) progenitors in the bone marrow. KIT is a cytokine receptor expressed on the surface of hematopoietic stem cells as well as other cell types. Altered forms of this receptor may be associated with some types of cancer. KIT D816V is a mutant of KIT. KIT D816V Recombinant Human Active Protein Kinase is a recombinant KIT D816V protein that can be used to study KIT D816V-related functions.
