3080682-14-7
3080682-14-7
Chemical Structure
Kit-IN-2
- CAS No.: 3080682-14-7
- Formula:C20H17FN6O
- Molecular Weight:376.39
InChIKey: DCMADICIGZKPTE-UHFFFAOYSA-N
SMILES: CC1=C(C=C(C(F)=C1)C2=NN=C(N2)C3CC3)NC(C4=C5C=CC=CN5N=C4)=O
Biological Activity: Kit-IN-2 is an orally active and highly selective KIT inhibitor. Kit-IN-2 stabilizes the inactive (DFG-out) conformation of KIT. Kit-IN-2 inhibits mast cell-mediated inflammatory responses by blocking stem cell factor-induced ear swelling and vascular permeability in rats. Kit-IN-2 exhibits favorable pharmacokinetic properties in rats. Kit-IN-2 can be used for studies related to acute allergy[1].
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Kit-IN-2 | Kit-IN-2 is an orally active and highly selective KIT inhibitor. Kit-IN-2 stabilizes the inactive (DFG-out) conformation of KIT. Kit-IN-2 inhibits mast cell-mediated inflammatory responses by blocking stem cell factor-induced ear swelling and vascular permeability in rats. Kit-IN-2 exhibits favorable pharmacokinetic properties in rats. Kit-IN-2 can be used for studies related to acute allergy. | |||||||||||||||||||||
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