1779796-38-1
Chemical Structure
PLX647 dihydrochloride
- CAS No.: 1779796-38-1
- Formula:C21H19Cl2F3N4
- Molecular Weight:455.30
IUPAC Name: 5-((1H-pyrrolo[2,3-b]pyridin-3-yl)methyl)-N-(4-(trifluoromethyl)benzyl)pyridin-2-amine dihydrochloride
InChIKey: MVMKWLRKACAUTB-UHFFFAOYSA-N
SMILES: FC(F)(F)C1=CC=C(CNC2=CC=C(CC3=CNC4=NC=CC=C43)C=N2)C=C1.Cl.Cl
Biological Activity: PLX647 dihydrochloride is an orally active, highly specific dual FMS and KIT kinase inhibitor, with IC50s of 28 and 16 nM, reapectively. PLX647 dihydrochloride shows selectivity for FMS and KIT over a panel of 400 kinases at a concentration of 1 μM except FLT3 and KDR (IC50s=91 and 130 nM, respectively)[1].
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PLX647 dihydrochloride | PLX647 dihydrochloride is an orally active, highly specific dual FMS and KIT kinase inhibitor, with IC50s of 28 and 16 nM, reapectively. PLX647 dihydrochloride shows selectivity for FMS and KIT over a panel of 400 kinases at a concentration of 1 μM except FLT3 and KDR (IC50s=91 and 130 nM, respectively). | |||||||||||||||||||||
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Keywords
