c-Kit-IN-15
c-Kit-IN-15 is a c-Kit inhibitor. c-Kit-IN-15 inhibits the c-Kit signaling pathway and suppresses cancer cell proliferation. c-Kit-IN-15 can be used in research related to hepatocellular carcinoma and breast cancer.
商品は「研究用試薬」です。人や動物の医療用・臨床診断用・食品用の製品ではありません。
研究用途以外に使用した場合、当社は一切の責任を負いかねます。
- 分子式: C39H55NO3
- 分子量:585.86
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保管条件:
Please store the product under the recommended conditions in the Certificate of Analysis.
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生物活性
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化学情報
- 純度とドキュメンテーション
- 参考文献
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Help & FAQs
生物活性
c-Kit-IN-15 (Compound I9) (10 μM, 48 h) potently inhibits the proliferation of HepG-2 and MCF-7 cells, with IC50 values of 8.94 μM and 9.64 μM, respectively[1].
c-Kit-IN-15 (3-9 μM) downregulates the expression of c-Kit protein in MCF-7 cells in a concentration-dependent manner[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Cell Line:human hepatocellular carcinoma HepG-2 cells, human breast cancer MCF-7 cells
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Concentration:10 μM; tested for IC50 determination
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Incubation Time:48 h
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Result:Inhibited HepG-2 cell proliferation by 55.29% and MCF-7 cell proliferation by 50.44%.
Exhibited an IC50 of 8.94 μmol/L in HepG-2 cells and 9.64 μmol/L in MCF-7 cells.
化学情報
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分子量 585.86
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分子式 C39H55NO3
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SMILES
O=C([C@]12CCC(C)(CC1C3=CCC4[C@]5(C=CC(C(C)(C5CC[C@]4([C@@]3(CC2)C)C)C)=O)C)C)OCCNC6=CC=CC(C)=C6
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輸送条件
Room temperature in continental US; may vary elsewhere.
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保管条件
Please store the product under the recommended conditions in the Certificate of Analysis.
純度とドキュメンテーション
参考文献
Calculators
濃度 (開始) × 体積 (開始) = 濃度 (終了) × 体積 (終了)
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