SERPINB4 - serpin family B member 4 Gene

Also Known as PI11; SCCA1; SCCA2; LEUPIN; SCCA-2

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 6318

About SERPINB4

Cytogenetic location: 18q21.33 Genomic coordinates (GRCh38): 18:63,637,259-63,644,256 (from NCBI)

This gene has 4 transcripts (splice variants), 222 orthologues and 36 paralogues. Biased expression in esophagus (RPKM 63.1), urinary bladder (RPKM 11.6) and 1 other tissue.

Summary

The protein encoded by this gene is a member of the Serpin family of serine Protease Inhibitors. The encoded protein is highly expressed in many tumor cells and can inactivate granzyme M, an enzyme that kills tumor cells. This protein, along with Serpin B3, can be processed into smaller fragments that aggregate to form an autoantigen in psoriasis, probably by causing chronic inflammation. [provided by RefSeq, Jan 2017]

SERPINB4 Products (2)

mRNA Protein Name
NM_002974.4 NP_002965.1 serpin B4 isoform 1
NM_175041.2 NP_778206.1 serpin B4 isoform 2

Gene Ontology

  • Molecular Function
  • Biological Process
Molecular Function GO Annotation Evidence Verweise Source
enables enzyme binding IPI
IPI: Inferred from physical interaction
23382074 GOA
enables protease binding IPI
IPI: Inferred from physical interaction
21857942 GOA
enables protein binding IPI
IPI: Inferred from physical interaction
28514442 GOA
enables serine-type endopeptidase inhibitor activity IDA
IDA: Inferred from direct assay
21857942 GOA
Biological Process GO Annotation Evidence Verweise Source
involved in negative regulation of peptidase activity IDA
IDA: Inferred from direct assay
12949073 GOA
involved in protection from natural killer cell mediated cytotoxicity IMP
IMP: Inferred from mutant phenotype
21857942 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

SERPINB4 Protein Structure

Serpin

Serpin: Serpin (serine protease inhibitor) (6 - 390)

  • 0
  • 100
  • 200
  • 300
  • 390 a.a.
Protein Preferred Names Protein Names

serpin B4

  • SCCA2/SCCA1 fusion protein

SERPINB4 Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method Verweise
Intra
SERPINB4 P48594 SERPINB3 Homo sapiens P29508
Anti Tag CoIP
33961781
Cross: Cross-species interaction Intra: Intraspecies interaction

Recombinant SERPINB4 Proteins

Art. -Nr. Produktname Accession Reinheit
HY-P77198 Serpin B4 Protein, Human (sf9, His) P48594 (M1-P390) ≥ 85%, as determined by reducing SDS-PAGE.

Related Diseases

Diseases Alias
Squamous Cell Carcinoma

  • Epidermoid Carcinoma

  • Squamous Cell Cancer

  • Carcinoma, Squamous Cell

  • Squamous Cell Skin Cancer

  • Malignant Squamous Cell Tumor

  • Squamous Carcinoma

  • Squamous Cell Epithelioma

  • Carcinoma Squamous Cell

  • Neoplasms, Squamous Cell

  • Squamous Cell Carcinoma - Category

  • Malignant Squamous Cell Neoplasm

  • Squamous Cell Carcinoma Of Skin
Maxillary Sinus Inverted Papilloma

  • Inverted Papilloma Of The Maxillary Sinus
Maxillary Sinus Benign Neoplasm

  • Neoplasm Of Maxillary Sinus

  • Tumor Of Maxillofacial Sinus

  • Maxillary Sinus Neoplasms

  • Maxillary Sinus Neoplasm
Psoriasis
Acute Frontal Sinusitis
Cervical Squamous Cell Carcinoma

  • Squamous Cell Carcinoma Of The Cervix Uteri

  • Squamous Cell Carcinoma Of Cervix
Childhood Central Nervous System Primitive Neuroectodermal Neoplasm

  • Pediatric Cns Pnet

  • Childhood Central Nervous System Primitive Neuroectodermal Tumor
Cervical Cancer

  • Cervical Cancer, Somatic

  • Neoplasm Of Uterine Cervix

  • Cervix Cancer

  • Uterine Cervical Neoplasm

  • Cervical Neoplasm

  • Cervix Uteri Cancer

  • Tumor Of The Cervix Uteri

  • CERCA

  • Uterine Cervical Cancer

  • Neoplasms Cervical

  • Uterine Cervical Neoplasms

  • Cervical Cancers

  • Cancer, Cervical, Somatic

  • Malignant Tumor Of Cervix

  • Cervix Carcinoma
Asthma

  • Chronic Obstructive Asthma

  • Asthma, Diminished Response To Antileukotriene Treatment In

  • Bronchial Hyperreactivity

  • Asthma, Susceptibility To

  • Asthma, Bronchial

  • Asthma, Protection Against

  • Asthma, Nocturnal, Susceptibility To

  • Nocturnal Asthma

  • Asthma-Related Traits

  • Asthma-Related Traits, Susceptibility To

  • Asthma, Nocturnal

  • Chronic Obstructive Asthma With Acute Exacerbation

  • Chronic Obstructive Asthma With Status Asthmaticus

  • Exercise Induced Asthma

  • Exercise-Induced Asthma

  • Bronchial Asthma

  • Asthma, Exercise-Induced

  • Idiosyncratic Asthma

  • Unspecified Asthma With Acute Exacerbation

  • Asthma, Unspecified, With Stated Status Asthmaticus

  • Status Asthmaticus Nos

  • Acute Severe Asthma

  • Acute Severe Bronchial Asthma

  • Status Asthma

  • Status Post Asthmaticus
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)
Art. -Nr. Produktname
Wirkung
Reinheit
Rare Diseases
HY-RS12712 SERPINB4 Human Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Rattus norvegicus SERPINB4 RGD RGD:1562868