Im-m7GDP
Im-m7GDP is a capping reagent and also the P-imidazolide of N7-methylguanosine 5'-diphosphate. Im-m7GDP introduces an m7G cap structure to the monophosphate group of branched oligoribonucleotides, and is used in nucleic acid synthesis-related research.
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- CAS. Nr.: 531553-69-2
- Formel: C14H19N7O10P2
- Molecular Weight:507.29
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Speicherung:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Biologische Aktivität
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Chemical Information
- Reinheit & Dokumentation
- Verweise
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Help & FAQs
Biologische Aktivität
Beschreibung
In Vitro
Im-m7GDP (10 mM; 3 h) efficiently introduces an m7G cap structure to the 5′ phosphorylated branched strand of synthetic oligoribonucleotides under the specified reaction conditions[2].
Im-m7GDP (10 mM; 3 h) effectively introduces a cap structure onto 5′-monophosphorylated 68-nt chemically synthesized RNA in a cell-free in vitro reaction[3].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Parmacokinetics
| Species | Dose | Route |
|---|---|---|
| Human | 2 ng·h | i.v. |
Chemical Information
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CAS. Nr. 531553-69-2
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Molecular Weight 507.29
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Formel C14H19N7O10P2
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SMILES
O=C1C([N+](C)=CN2[C@H]3[C@H](O)[C@H](O)[C@@H](COP([O-])(OP(O)(N4C=CN=C4)=O)=O)O3)=C2NC(N)=N1
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Versand
Room temperature in continental US; may vary elsewhere.
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Speicherung
Please store the product under the recommended conditions in the Certificate of Analysis.
Reinheit & Dokumentation
Verweise
[1]. Geng J, et al. Cap-related modifications of RNA regulate binding to IFIT proteins. RNA (New York, N.Y.). 2024 Sep 16;30(10):1292-1305. [Content Brief]
[2]. Fukuchi K, et al. Internal cap-initiated translation for efficient protein production from circular mRNA. Nature biotechnology. 2026 Jan;44(1):120-132. [Content Brief]
[3]. Ohashi S, et al. Selection of Short 5'-UTR of Chemically Synthesized mRNA to Improve Translation Efficiency. Chemical & pharmaceutical bulletin. 2025;73(5):449-456. [Content Brief]
Calculators
Konzentration (Stammlösung) × Volumen (Stammlösung) = Konzentration (Ziellösung) × Volumen (Ziellösung)
Im-m7GDP Related Classifications
HY-178674 Related Classifications
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Keywords
- Im-m7GDP
- 531553-69-2
- Biochemical Assay Reagents
- Nucleoside Antimetabolite/Analog
- m7G cap structure
- C57BL6N mice
- HiBiT peptide
- branched oligoribonucleotides
- chemically synthesized mRNA
- synthetic oligoribonucleotides
- chemically synthesized RNA
- Balb/c mice
- N7-methylguanosine 5′-diphosphate
- trinucleotide cap analogs
- Inhibitor
- inhibitor
- inhibit