167 Results for "

quinone

" in MedChemExpress (MCE) Product Catalog:
Products (167)

167 Results for "quinone" in MCE Product Catalog:

11
Dicoumarol
Dicoumarol
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11 Publications Verification
Art. -Nr.: HY-N0645
CAS. Nr.: 66-76-2
Synonyms: Dicumarol
Category:  

Melilotus officinalis (L.) Pall. Leguminosae Coumarins Phenylpropanoids Plants Disease Research Fields Biological Pesticide Research Cancer Agricultural Research

Target:  

Quinone Reductase PDHK

Dicoumarol is an inhibitor of both NAD(P)H:quinone oxidoreductase 1 (NQO1) and PDK1 with IC50s of 0.37 and 19.42 μM, respectively.
8
Pyrroloquinoline quinone
Pyrroloquinoline quinone
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8 Cited Publications
Art. -Nr.: HY-100196
CAS. Nr.: 72909-34-3
Reinheit:  99.82%
Synonyms: PQQ; Methoxatin
Category:  

Quinones Microorganisms Animals Benzene Quinones Endogenous metabolite Disease Research Fields Inflammation/Immunology

Target:  

Endogenous Metabolite

Pyrroloquinoline quinone (PQQ), a redox co-factor, is an anionic, redox-cycling orthoquinone. Pyrroloquinoline quinone is isolated from cultures of methylotropic bacteria and tissues of mammals. Pyrroloquinoline quinone is an essential nutrient for mammals and is important for immune function .
8
Pyrroloquinoline quinone disodium salt
Pyrroloquinoline quinone disodium salt
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8 Cited Publications
Art. -Nr.: HY-100196A
CAS. Nr.: 122628-50-6
Reinheit:  ≥98.0%
Synonyms: PQQ disodium salt; Methoxatin disodium salt
Category:  

Quinones Microorganisms Benzene Quinones Endogenous metabolite Disease Research Fields Inflammation/Immunology

Target:  

Endogenous Metabolite

Pyrroloquinoline quinone disodium salt, a redox co-factor, is an anionic, redox-cycling orthoquinone. Pyrroloquinoline quinone disodium salt is isolated from cultures of methylotropic bacteria and tissues of mammals. Pyrroloquinoline quinone disodium salt is an essential nutrient for mammals and is important for immune function .
7
6PPD-Q
6PPD-Q
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7 Cited Publications
Art. -Nr.: HY-153169
CAS. Nr.: 2754428-18-5
Reinheit:  99.30%
Synonyms: 6PPD-quinone
Category:  

Alkaloids Quinones Other Alkaloids Other Diseases Benzene Quinones Endogenous metabolite Disease Research Fields

Target:  

α-synuclein Environmental Pollutants

6PPD-Q (6PPD-Quinone) is an environmental pollutant that can be detected in human urine and is widely present in the environment. 6PPD-Q targets and binds to CNR2, CNR1, AA2AR, LCAT, and TRPA1, with CNR2 exhibiting the highest binding affinity, potentially acting as a CNR2 receptor agonist to activate cannabinoid receptors. 6PPD-Q induces intestinal inflammation and barrier damage by disrupting mitochondrial function, reducing neuronal glycolysis metabolites and TCA cycle intermediates, and exacerbating α-synuclein (α-syn) aggregation. 6PPD-Q is applicable in research on environmental toxicology, neurodegenerative diseases, and inflammation-related disorders .
4
INCA-6
INCA-6
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4 Cited Publications
Art. -Nr.: HY-108544
CAS. Nr.: 3519-82-2
Reinheit:  98.85%
Synonyms: Triptycene-1,4-quinone
Target:  

Nuclear Factor of activated T Cells (NFAT)

Forschungsgebiete:  

Cardiovascular Disease

INCA-6 (Triptycene-1,4-quinone) is a cell-permeable NFAT inhibitor. INCA-6 specifically blocks targeting of NFAT(P) substrate to the calcineurin (CN) phosphatase site and is an effective inhibitor of CN-NFAT signaling .
3
2-HBA
2-HBA
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3 Cited Publications
Art. -Nr.: HY-103667
CAS. Nr.: 131359-24-5
Reinheit:  99.46%
Target:  

Quinone Reductase Caspase

Forschungsgebiete:  

Cancer

2-HBA is a potent inducer of NAD(P)H:quinone acceptor oxidoreductase 1 (NQO1) which can also activate caspase-3 and caspase-10.
2
FC9402
FC9402
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2 Cited Publications
Art. -Nr.: HY-141552
CAS. Nr.: 2452401-65-7
Reinheit:  99.61%
Target:  

Mitochondrial Metabolism

Forschungsgebiete:  

Cardiovascular Disease

FC9402 is a potent and selective sulfide quinone oxidoreductase (SQOR) inhibitor extracted from patent WO 2020/146636 A1. FC9402 attenuates TAC-induced cardiomyocyte hypertrophy and left ventricle (LV) fibrosis. FC9402 can be used for cardiovascular regulation .
2
Rifamycin S
Rifamycin S
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2 Cited Publications
Art. -Nr.: HY-125365
CAS. Nr.: 13553-79-2
Reinheit:  98.82%
Category:  

Infection Quinones Microorganisms Monophenols Phenols Disease Research Fields Naphthalene Quinones

Target:  

Bacterial Reactive Oxygen Species (ROS) Antibiotic

Rifamycin S, a quinone, is an antibiotic against Gram-positive bacteria (including MRSA). Rifamycin S is the oxidized forms of a reversible oxidation-reduction system involving two electrons. Rifamycin S generates reactive oxygen species (ROS) and inhibits microsomal lipid peroxidation. Rifamycin S can be used for tuberculosis and leprosy .
2
S29434
S29434
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2 Cited Publications
Art. -Nr.: HY-122614
CAS. Nr.: 874484-20-5
Reinheit:  99.29%
Synonyms: NMDPEF
Target:  

Autophagy

Forschungsgebiete:  

Neurological Disease

S29434 (NMDPEF) is a potent, competitive, selective and cell-permeable inhibitor of quinone reductase 2 (QR2), with IC50s ranging from 5 to 16 nM for human QR2 at different organizational levels, and has good selectivity for QR2 over QR1. S29434 induces autophagy and inhibits QR2-mediated ROS production .
1
Przewaquinone A
Przewaquinone A
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1 Cited Publications
Art. -Nr.: HY-N1551
CAS. Nr.: 76843-23-7
Category:  

Quinones Labiatae Diterpenoids Plants Naphthalene Quinones Vachellia nilotica (L.) P. J. H. Hurter & Mabb.

Target:  

Others

Przewaquinone A, a lipophilic diterpene quinone present only in Salvia przewalskii, induces a potent inhibitory action on vascular contraction .
1
Physalin A
Physalin A
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1 Cited Publications
Art. -Nr.: HY-N9942
CAS. Nr.: 23027-91-0
Category:  

Alkekengi officinarum var. franchetii (Mast.) R.J.Wang Ketones, Aldehydes, Acids Plants Solanaceae Disease Research Fields Cancer

Target:  

Apoptosis Autophagy NF-κB p38 MAPK PI3K Akt mTOR STAT JAK

Physalin A is a biologically active withanolide. Physalin A shows anti-inflammatory, antifibrotic and ameliorative effects on autophagy in models of disc degeneration. Physalin A has antitumor activity and can induce apoptosis, ROS production and G2/M phase cell cycle arrest. Besides. Physalin A can significantly increase the activity of quinone reductase and increase the expression of detoxifying enzymesc .
1
H-Tyr-OMe
H-Tyr-OMe
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1 Cited Publications
Art. -Nr.: HY-W007671
CAS. Nr.: 1080-06-4
Category:  

Monophenols Other Diseases Phenols Amino acids Endogenous metabolite Disease Research Fields

Target:  

Endogenous Metabolite Tyrosinase

H-Tyr-OMe is an endogenous metabolite. H-Tyr-OMe quenches the fluorescence of carbon dots by oxidizing the phenolic hydroxyl group to quinone under the catalysis of Tyrosinase, and its amino and thiol binding ability can respond to changes in the concentration of biothiols .
1
Xanthohumol D
Xanthohumol D
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1 Cited Publications
Art. -Nr.: HY-N1066
CAS. Nr.: 274675-25-1
Category:  

Flavonoids Chalcones Humulus lupulus L. Phenols Polyphenols Plants Moraceae Disease Research Fields Cancer

Target:  

Others

Xanthohumol D, isolated from hops, is an inhibitor of quinone reductase-2 (QR-2) with the IC50 value of 110 μM, and binds to the active site of QR-2. Xanthohumol D shows antiproliferative activity on human cancer cell lines in vitro .
1
Azoreductase/NQO1 Protein, Human
Azoreductase/NQO1 Protein, Human
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1 Cited Publications
Art. -Nr.: HY-P74405A
Reinheit:  ≥ 95%, as determined by reducing SDS-PAGE.
Synonyms: NQO1; DIA4; NAD(P)H dehydrogenase [quinone] 1; Azoreductase; DTD; QR1
Species:  
Human
Source:  
E. coli
1
KL1333
KL1333
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1 Cited Publications
Art. -Nr.: HY-128895
CAS. Nr.: 1800405-30-4
Reinheit:  99.94%
Target:  

Quinone Reductase Mitochondrial Metabolism

Forschungsgebiete:  

Metabolic Disease

KL1333, a derivative of β-lapachone, is an orally available NAD+ modulator. KL1333 reacts with NAD(P)H:quinone oxidoreductase 1 (NQO1) as a substrate, resulting in increases in intracellular NAD+ levels via NADH oxidation. KL1333 improves energy metabolism and mitochondrial dysfunction in MELAS fibroblasts. KL1333 protects against Cisplatin-induced ototoxicity in mouse cochlear cultures .
1
PQQ-trimethylester
PQQ-trimethylester
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1 Cited Publications
Art. -Nr.: HY-160831
CAS. Nr.: 74447-88-4
Synonyms: PQQ-TME
Target:  

α-synuclein

Forschungsgebiete:  

Neurological Disease

PQQ-trimethylester (PQQ-TME) is a synthetic compound that is a trimethylester derivative of pyrroloquinoline quinone (PQQ). PQQ-trimethylester has twice the blood-brain barrier permeability of PQQ (HY-100196) in vitro. In addition, PQQ-trimethylester shows strong inhibitory activity against α-synuclein, amyloid β1-42 (Aβ1-42) and prion protein fibrillation. PQQ-trimethylester can be used in the study of neurodegenerative diseases .
1
Dabigatran ethyl ester
Dabigatran ethyl ester
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1 Cited Publications
Art. -Nr.: HY-17378
CAS. Nr.: 429658-95-7
Target:  

Thrombin

Forschungsgebiete:  

Cardiovascular Disease

Dabigatran ethyl ester is an inhibitor of ribosyldihydronicotinamide dehydrogenase (NQO2) and thrombin. Dabigatran ethyl ester inhibits NADH-dependent metabolism of mitomycin C mediated by purified recombinant human NQO2 .
6PPD-quinone-d5
6PPD-quinone-d5
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Art. -Nr.: HY-152039S
CAS. Nr.: 2750119-14-1
Reinheit:  99.39%
6PPD-quinone-d5 is the deuterium labeled 6PPD-quinone .
Isobutyl-deoxynyboquinone
Isobutyl-deoxynyboquinone
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Art. -Nr.: HY-125027
CAS. Nr.: 1430798-22-3
Reinheit:  99.70%
Synonyms: IB-DNQ
Target:  

Quinone Reductase

Forschungsgebiete:  

Cancer

Isobutyl-deoxynyboquinone (IB-DNQ) is a selective substrate for NAD(P)H:quinone oxidoreductase (NQO1). Isobutyl-deoxynyboquinone can be used for the research of anticancer .
Neochlorogenic acid methyl ester
Neochlorogenic acid methyl ester
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Art. -Nr.: HY-N4168A
CAS. Nr.: 123410-65-1
Synonyms: 5-O-Caffeoylquinic acid methyl ester
Category:  

Caprifoliaceae Lonicera japonica Thunb. Phenols Polyphenols Plants

Target:  

Quinone Reductase HBV

Neochlorogenic acid (5-O-Caffeoylquinic) methyl ester is a selective quinone reductase inducer (EC50 = 6.7 μM) and also exhibits hydroxyl radical scavenging activity (EC50 = 0.81 μM). Neochlorogenic acid methyl ester scavenges hydroxyl radicals by donating electrons or hydrogen atoms, while simultaneously inducing quinone reductase expression to enhance carcinogen detoxification, thus exerting antioxidant and cancer chemopreventive activities. Neochlorogenic acid methyl ester is used in research on antioxidant damage and promoting detoxification metabolism, primarily in the fields of cancer chemotherapy and antioxidant-related diseases. Neochlorogenic acid methyl ester is also an HBV inhibitor and can be isolated from the flower buds of *L. japonica* .
Assay Types