274675-25-1
274675-25-1
Chemical Structure
Xanthohumol D
- CAS 番号: 274675-25-1
- Formula:C21H22O6
- Molecular Weight:370.40
IUPAC Name: (E)-1-(2,4-dihydroxy-3-(2-hydroxy-3-methylbut-3-en-1-yl)-6-methoxyphenyl)-3-(4-hydroxyphenyl)prop-2-en-1-one
InChIKey: IIWLGOCXDBSFCM-RMKNXTFCSA-N
SMILES: O=C(C1=C(OC)C=C(O)C(CC(O)C(C)=C)=C1O)/C=C/C2=CC=C(O)C=C2
Biological Activity: Xanthohumol D, isolated from hops, is an inhibitor of quinone reductase-2 (QR-2) with the IC50 value of 110 μM, and binds to the active site of QR-2. Xanthohumol D shows antiproliferative activity on human cancer cell lines in vitro[1][2].
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Xanthohumol D | 99.21% | Xanthohumol D, isolated from hops, is an inhibitor of quinone reductase-2 (QR-2) with the IC50 value of 110 μM, and binds to the active site of QR-2. Xanthohumol D shows antiproliferative activity on human cancer cell lines in vitro. | ||||||||||||||||||||
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Structural Analogs
-
Similarity Score 0.79
HY-N1067A(E/Z)-Xanthohumol -
Similarity Score 0.79
HY-N1067RXanthohumol (Standard) -
Similarity Score 0.75
HY-115918XA-E -
Similarity Score 0.71
HY-N18513'-Methylflavokawin -
Similarity Score 0.70
HY-122966Desmethylxanthohumol -
Similarity Score 0.69
HY-121381Kuraridine -
Similarity Score 0.69
HY-N18503'-Methyl-4-O-methylhelichrysetin -
Similarity Score 0.69
HY-N4058Helichrysetin -
Similarity Score 0.68
HY-N2445Flavokawain C -
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References
- [1]. Choi Y, et al. Screening natural products for inhibitors of quinone reductase-2 using ultrafiltration LC-MS. Anal Chem. 2011 Feb 1;83(3):1048-52. [Content Brief]
- [2]. Tronina T, et al. Fungal metabolites of xanthohumol with potent antiproliferative activity on human cancer cell lines in vitro. Bioorg Med Chem. 2013 Apr 1;21(7):2001-6. [Content Brief]
