Uridine triphosphate
Based on 4 publication(s) in Google Scholar
Uridine triphosphate (UTP; Uridine 5'-triphosphate) is a pyrimidine nucleoside triphosphate that is used as a substrate to synthesize RNA or as an energy source in metabolic reactions. Uridine triphosphate activates membrane-bound P2Y2 receptors.
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- CAS No.: 63-39-8
- Formula: C9H15N2O15P3
- Molecular Weight:484.14
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Storage:Powder -20°C, 3 years , 4°C, 2 years
* The compound is unstable in solutions, freshly prepared is recommended.
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Biological Activity
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Chemical Information
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Solvent & Solubility
- Purity & Documentation
- References
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Help & FAQs
Publications Citing Use of MedChemExpress (MCE) Uridine triphosphate
MoreAll Endogenous Metabolite Isoforms
MoreAll DNA/RNA Synthesis Isoforms
MoreAll P2Y Receptor Isoforms
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Biological Activity
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Human Endogenous Metabolite |
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Cell Line
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Type | Value | Description | References |
|---|---|---|---|---|
| A549 | EC50 |
0.45 μM
Compound: UTP
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Activity against human P2Y2-GFP expressed in A549 cells by intracellular calcium increase
Activity against human P2Y2-GFP expressed in A549 cells by intracellular calcium increase
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[PMID: 16539385] |
| HEK293 | EC50 |
0.13 μM
Compound: UTP
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Activity against rat P2Y2-GFP transfected in HEK293 cells by intracellular calcium increase
Activity against rat P2Y2-GFP transfected in HEK293 cells by intracellular calcium increase
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[PMID: 16539385] |
| NG108-15 | EC50 |
1.26 μM
Compound: UTP
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Agonist activity at mouse P2Y2 receptor expressed in NG108-15 hybrid cells assessed as increase in intracellular calcium release by fluorescence assay
Agonist activity at mouse P2Y2 receptor expressed in NG108-15 hybrid cells assessed as increase in intracellular calcium release by fluorescence assay
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[PMID: 19523835] |
| NG108-15 | IC50 |
1.51 μM
Compound: UTP
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Antagonist activity at mouse P2Y2 receptor expressed in NG108-15 hybrid cells assessed as inhibition of 1 uM UTP-induced intracellular calcium release preincubated 30 mins before UTP challenge by fluorescence assay
Antagonist activity at mouse P2Y2 receptor expressed in NG108-15 hybrid cells assessed as inhibition of 1 uM UTP-induced intracellular calcium release preincubated 30 mins before UTP challenge by fluorescence assay
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[PMID: 19523835] |
Uridine triphosphate enhances the migration and wound repair of RT4-D6P2T cells by activating the P2Y2 receptor and increasing the activation and expression of extracellular MMP-2[2].
Uridine triphosphate induces MAPK phosphorylation in a biphasic manner. It causes early transient phosphorylation within 5 minutes after treatment, and late persistent phosphorylation occurs 6 hours later, lasting for up to 24 hours[2].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Cell Line:RT4-D6P2T cells
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Concentration:250 µM
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Incubation Time:5 min, 45 min, 2 h, 6 h, 12 h, 24 h, 48 h
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Result:Induces biphasic MAPK phosphorylation.
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Animal Model:Male Wistar rats (250-300 g; 2-3 months) with myocardial infarction (MI)[3]
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Dosage:0.44 µg/kg 30 min before MI, and 4.4 µg/kg i.v. 24 h prior to MI.
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Administration:i.v.; once
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Result:Reduced infarct size and improves rat heart function after myocardial infarct.
Chemical Information
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CAS No. 63-39-8
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Appearance Solid
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Molecular Weight 484.14
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Formula C9H15N2O15P3
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Color White to off-white
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SMILES
O=C(N1[C@H]2[C@H](O)[C@H](O)[C@@H](COP(O)(OP(OP(O)(O)=O)(O)=O)=O)O2)NC(C=C1)=O
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Synonyms
UTP; Uridine 5'-triphosphate
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Structure Classification
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Initial Source
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Powder -20°C 3 years 4°C 2 years * The compound is unstable in solutions, freshly prepared is recommended.
Publications (4)
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Journal Impact Factor
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Most Recent
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Nature
2025 Jul;643(8070):192-200. PMID: 39695227 -
Cell
Cyclic-dinucleotide-induced filamentous assembly of phospholipases governs broad CBASS immunity. [Abstract]2025 Jul 10;188(14):3744-3756.e16. PMID: 40345202 -
Life Sci
2023 Sep 1:328:121896. PMID: 37385371 -
Anal Chim Acta
2021 Dec 15:1188:339180. PMID: 34794559
Solvent & Solubility
H2O : ≥ 150 mg/mL (309.83 mM)
* "≥" means soluble, but saturation unknown.
Please refer to the solubility information to select the appropriate solvent. The compound is unstable in solutions, freshly prepared is recommended.
* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.
Please refer to the solubility information to select the appropriate solvent. The compound is unstable in solutions, freshly prepared is recommended.
* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
For the following dissolution methods, please prepare the working solution directly:
It is recommended to prepare fresh solutions and use them promptly within a short period of time.
The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.
Add each solvent one by one: PBS
Solubility: 100 mg/mL (206.55 mM); Clear solution; Need ultrasonic
Purity & Documentation
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Data Sheet (278 KB)
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SDS (252 KB)
- English - EN (252 KB)
- Français - FR (252 KB)
- Deutsch - DE (252 KB)
- Norwegian - NO (252 KB)
- Español - ES (252 KB)
- Swedish - SV (252 KB)
- Italian - IT (252 KB)
- Korean - KR (252 KB)
- Portuguese - PT (252 KB)
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Handling Instructions (2659 KB)
References
[1]. Choi JH, et al. Uridine triphosphate increases proliferation of human cancerous pancreatic duct epithelial cells by activating P2Y2 receptor. Pancreas. 2013 May;42(4):680-6. [Content Brief]
[2]. Lamarca A, et al. Uridine 5'-triphosphate promotes in vitro Schwannoma cell migration through matrix metalloproteinase-2 activation. PLoS One. 2014 Jun 6;9(6):e98998. [Content Brief]
[3]. Yitzhaki S, et al. Uridine-5'-triphosphate (UTP) reduces infarct size and improves rat heart function aftermyocardial infarct. Biochem Pharmacol. 2006 Oct 16;72(8):949-55. [Content Brief]
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. The compound is unstable in solutions, freshly prepared is recommended.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| H2O | 1 mM | 2.0655 mL | 10.3276 mL | 20.6552 mL | 51.6380 mL |
| 5 mM | 0.4131 mL | 2.0655 mL | 4.1310 mL | 10.3276 mL | |
| 10 mM | 0.2066 mL | 1.0328 mL | 2.0655 mL | 5.1638 mL | |
| 15 mM | 0.1377 mL | 0.6885 mL | 1.3770 mL | 3.4425 mL | |
| 20 mM | 0.1033 mL | 0.5164 mL | 1.0328 mL | 2.5819 mL | |
| 25 mM | 0.0826 mL | 0.4131 mL | 0.8262 mL | 2.0655 mL | |
| 30 mM | 0.0689 mL | 0.3443 mL | 0.6885 mL | 1.7213 mL | |
| 40 mM | 0.0516 mL | 0.2582 mL | 0.5164 mL | 1.2909 mL | |
| 50 mM | 0.0413 mL | 0.2066 mL | 0.4131 mL | 1.0328 mL | |
| 60 mM | 0.0344 mL | 0.1721 mL | 0.3443 mL | 0.8606 mL | |
| 80 mM | 0.0258 mL | 0.1291 mL | 0.2582 mL | 0.6455 mL | |
| 100 mM | 0.0207 mL | 0.1033 mL | 0.2066 mL | 0.5164 mL |
* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.
Uridine triphosphate Related Classifications
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