Anticancer agent 315
Anticancer agent 315 is an antitumor agent. Anticancer agent 315 binds to the active pocket of thymidylate synthase via forming strong hydrogen bonds with Lys487 and Ala498, stabilizing the arrangement of the ligand within the pocket. Anticancer agent 315 inhibits the proliferation of tumor cells. Anticancer agent 315 can be used for the research of liver cancer and breast cancer.
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- Formule: C23H17N11O3S
- Masse moléculaire:527.52
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Stockage:
Please store the product under the recommended conditions in the Certificate of Analysis.
To place orders, for customer services and technical support, please contact: MedChemExpress USA
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Activité biologique
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Chemical Information
- Pureté et documentation
- Références
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Help & FAQs
Activité biologique
Anticancer agent 315 (compound 23) potently inhibits the viability of HepG2 and MCF-7 cancer cells, while exhibiting low toxicity toward WI-38 and VERO normal cells[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Cell Line:HepG2 and MCF-7 cancer cells, WI-38 and VERO normal cells
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Concentration:/
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Incubation Time:/
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Result:Had IC50 values of 15.9 µM and 18.0 µM for HepG2 and MCF-7 cancer cells.
Had IC50 values of 40.2 µM and 45.7 µM for WI-38 and VERO normal cells.
Chemical Information
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Masse moléculaire 527.52
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Formule C23H17N11O3S
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SMILES
O=C(C1=C(N/N=C(C#N)/C#N)NN=C1NC2=CC=CC=C2)NC3=CC=C(S(=O)(NC4=NC=CC=N4)=O)C=C3
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Livraison
Room temperature in continental US; may vary elsewhere.
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Stockage
Please store the product under the recommended conditions in the Certificate of Analysis.
Pureté et documentation
Références
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Anticancer agent 315 Related Classifications
HY-183108 Related Classifications
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