LY6E - lymphocyte antigen 6 family member E Gene

Also Known as RIGE; SCA2; RIG-E; SCA-2; TSA-1

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 4061

About LY6E

Cytogenetic location: 8q24.3 Genomic coordinates (GRCh38): 8:143,018,529-143,022,409 (from NCBI)

This gene has 15 transcripts (splice variants), 1 gene allele, 148 orthologues and 2 paralogues. Ubiquitous expression in liver (RPKM 110.6), spleen (RPKM 88.2) and 24 other tissues.

Summary

This gene belongs to the human Ly6 gene family and encodes a glycosylphosphatidyl-inositol (GPI)-anchored cell surface protein. The protein plays an important role in T cell physiology, oncogenesis and immunological regulation. The protein is also involved in modulation of viral Infection by coronaviruses, SARS-CoV, MERS-CoV and SARS-CoV-2. [provided by RefSeq, Aug 2021]

LY6E Products (2)

mRNA Protein Name
NM_001127213.2 NP_001120685.1 lymphocyte antigen 6E precursor
NM_002346.3 NP_002337.1 lymphocyte antigen 6E precursor

Gene Ontology

  • Molecular Function
  • Biological Process
Molecular Function GO Annotation Evidence Références Source
enables protein binding IPI
IPI: Inferred from physical interaction
32296183 GOA
Biological Process GO Annotation Evidence Références Source
involved in negative regulation of viral entry into host cell IDA
IDA: Inferred from direct assay
32641482 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

LY6E Protein Structure

UPAR_LY6

UPAR_LY6: u-PAR/Ly-6 domain (23 - 99)

  • 0
  • 100
  • 131 a.a.
Protein Preferred Names Protein Names

lymphocyte antigen 6E

  • ly-6E

LY6E Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method Références
Intra
LY6E Q16553 TMEM140 Homo sapiens Q9NV12
Validated Y2H
32296183
Intra
LY6E Q16553 MFSD6 Homo sapiens Q6ZSS7
Validated Y2H
32296183
Intra
LY6E Q16553 TMEM19 Homo sapiens Q96HH6
Validated Y2H
32296183
Cross: Cross-species interaction Intra: Intraspecies interaction

Recombinant LY6E Proteins

Cat. No. Nom du produit Accession Pureté
HY-P71539 Lymphocyte antigen 6E/LY6E Protein, Human (His-SUMO) Q16553 (L21-S101) ≥ 90%, as determined by reducing SDS-PAGE.

Related Diseases

Diseases Alias
Acute Promyelocytic Leukemia

  • Leukemia, Acute Promyelocytic

  • Acute Myeloblastic Leukemia Type 3

  • Aml M3

  • APL

  • Leukemia, Acute Promyelocytic, Somatic

  • Aml With T(15

  • 17)(Q22

  • Q12)

  • (Pml/Raralpha) And Variants

  • Apml

  • Acute Myeloblastic Leukemia 3

  • Acute Myeloid Leukemia With T(15

  • 17)(Q22

  • Q12)

  • (Pml/Raralpha) And Variants

  • Acute Myeloblastic Leukaemia Type 3

  • Acute Myeloid Leukaemia M3

  • Acute Myeloid Leukemia M3

  • Acute Promyelocytic Leukaemia

  • M3 Anll

  • Myeloid Leukemia, Acute, M3

  • Leukemia Promyelocytic Acute

  • Leukemia, Promyelocytic, Acute

  • Leukemia, Acute, Promyelocytic
Hyperpigmentation With Or Without Hypopigmentation, Familial Progressive

  • FPHH

  • Melanosis Universalis Hereditaria

  • Muh

  • Familial Progressive Hyperpigmentation With Or Without Hypopigmentation

  • Hyperpigmentation, Familial Progressive, 2, Formerly

  • Fph2, Formerly

  • Hyperpigmentation With Or Without Hypopigmentation

  • Familial Progressive Hyper- And Hypopigmentation

  • Hyperpigmentation, Familial Progressive
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (4)
Cat. No. Nom du produit
Effect
Pureté
Rare Diseases
HY-185492 MC-cBu-Cit-seco-CBI dimer / Unkown
HY-RS07897 LY6E Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS18771 Ly6e Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS25259 Ly6e Rat Pre-designed siRNA Set A Pre-designed Set / Unkown
Inhibitory Antibodies (1)
Cat. No. Nom du produit
Effect
Pureté
Rare Diseases
HY-P992056 Anti-Human/Mouse LY6E Antibody (9B12) / Unkown

Orthologs Information

Species Symbol Source ID
Canis familiaris LY6E VGNC VGNC:42873
Rattus norvegicus LY6E RGD RGD:1565342
Felis catus LY6E VGNC VGNC:81668
Bos taurus LY6E VGNC VGNC:31089
Mus musculus LY6E MGD MGI:106651
Others LY6E NCBI