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SEC24C - SEC24 homolog C, COPII coat complex component Gene

Species: Homo sapiens

Gene Type: protein coding

Gene ID: 9632

About SEC24C

Cytogenetic location: 10q22.2 Genomic coordinates (GRCh38): 10:73,744,372-73,772,161 (from NCBI)

This gene has 7 transcripts (splice variants), 42 orthologues and is associated with 1 phenotype. Ubiquitous expression in esophagus (RPKM 30.5), thyroid (RPKM 29.8) and 25 other tissues.

Summary

The protein encoded by this gene is a member of the SEC24 subfamily of the SEC23/SEC24 family, which is involved in vesicle trafficking. The encoded protein has similarity to yeast Sec24p component of COPII. COPII is the coat protein complex responsible for vesicle budding from the ER. The product of this gene may play a role in shaping the vesicle, as well as in cargo selection and concentration. Alternatively spliced transcript variants encoding the same protein have been identified. [provided by RefSeq, Jul 2008]

SEC24C Products (2)

mRNA	Protein	Name
NM_004922.4	NP_004913.2	protein transport protein Sec24C
NM_198597.3	NP_940999.1	protein transport protein Sec24C

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Références	Source
enables SNARE binding	IPI IPI: Inferred from physical interaction	18843296	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	10075675	GOA
enables zinc ion binding	IDA IDA: Inferred from direct assay	18843296	GOA

Biological Process GO Annotation	Evidence	Références	Source
involved in COPII-coated vesicle cargo loading	IDA IDA: Inferred from direct assay	17499046	GOA
involved in endoplasmic reticulum to Golgi vesicle-mediated transport	IMP IMP: Inferred from mutant phenotype	20427317	GOA

Cellular Component GO Annotation	Evidence	Références	Source
part of COPII vesicle coat	IDA IDA: Inferred from direct assay	10075675	GOA
located in cytosol	IDA IDA: Inferred from direct assay	10075675	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

SEC24C Protein Structure

zf-Sec23_Sec24

Sec23_trunk

Sec23_BS

Sec23_helical

Gelsolin

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1094 a.a.

Protein Preferred Names	Protein Names
protein transport protein Sec24C	SEC24 family, member C

SEC24C Protein-protein interaction Information

Type	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	Références
Intra	SEC24C	P53992	MOS	Homo sapiens	P00540	Validated Y2H	25416956
Intra	SEC24C	P53992	MOS	Homo sapiens	P00540	Y2H Array	25416956
Intra	SEC24C	P53992	MOS	Homo sapiens	P00540	Y2H Array	31515488
Intra	SEC24C	P53992	SEC23B	Homo sapiens	Q15437	Y2H Pooling	16189514
Intra	SEC24C	P53992	SEC23B	Homo sapiens	Q15437	Y2H Array	31515488
Intra	SEC24C	P53992	SEC23B	Homo sapiens	Q15437	Anti Tag CoIP	35271311
Intra	SEC24C	P53992	SEC23A	Homo sapiens	Q15436	CoIP	10075675
Intra	SEC24C	P53992	SEC23A	Homo sapiens	Q15436	Anti Tag CoIP	35271311

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases	Alias
Chromosome 22q11.2 Deletion Syndrome, Distal	22q11.2 Deletion Syndrome Autosomal Dominant Opitz G/Bbb Syndrome Catch22 Cayler Cardiofacial Syndrome Conotruncal Anomaly Face Syndrome Digeorge Syndrome Sedlackova Syndrome Shprintzen Syndrome Velocardiofacial Syndrome 22q11.2 Distal Deletion Syndrome Distal 22q11.2 Microdeletion Syndrome 22q11.2ds Vcfs Velo-Cardio-Facial Syndrome Distal Chromosome 22q11.2 Deletion Syndrome Chromosome 22q11.2 Deletion Syndrome Distal Chromosome 22q11.2 Deletion Syndrome Deletion 22q11.2 Syndrome 22q11ds Catch 22 Digeorge Sequence Microdeletion 22q11.2 Monosomy 22q11 Takao Syndrome Distal Del(22)(Q11.2) Distal Monosomy 22q11.2 Catch 22 Syndrome Chromosome Deletion Syndrome 22q11.2, Distal
Craniolenticulosutural Dysplasia	Boyadjiev-Jabs Syndrome CLSD Cranio-Lenticulo-Sutural Dysplasia Cranio-Lenticulo-Sutural Dysplasia, Clsd
Anemia, Congenital Dyserythropoietic, Type Ii	Congenital Dyserythropoietic Anemia Type Ii CDAN2 Cda Ii Hereditary Erythroblastic Multinuclearity With Positive Acidified-Serum Test Cda Type Ii Congenital Dyserythropoietic Anemia Type 2 Hereditary Erythroblastic Multinuclearity With A Positive Acidified-Serum Test Sec23b-Cdg Congenital Dyserythropoietic Anemia, Type Ii Dyserythropoietic Anemia, Hempas Type Hempas Cda Type 2 Dyserythropoietic Anemia, Congenital, Type Ii Cda, Type Ii Congenital Dyserythropoietic Anaemia Type 2 Congenital Dyserythropoietic Anaemia Type Ii Anemia, Dyserythropoietic, Congenital Type 2 Hempas Anemia Dyserythropoietic Anemia, Congenital Type 2 Anemia, Congenital Dyserythropoietic, 2 Dyserythropoietic Anemia Hempas Type Anemia, Dyserythropoietic Congenital, Type Ii Anemia, Dyserythropoietic, Congenital, Type Ii
Chylomicron Retention Disease	CMRD Anderson Disease Lipid Transport Defect Of Intestine Hypobetalipoproteinemia With Accumulation Of Apolipoprotein B-Like Protein In Intestinal Cells Andd Anderson Syndrome Crd Andersons Disease Malabsorption Syndrome

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Nom du produit	Effect	Pureté	Rare Diseases
HY-RS12617	SEC24C Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Felis catus	SEC24C	VGNC	VGNC:64969
Mus musculus	SEC24C	MGD	MGI:1919746
Canis familiaris	SEC24C	VGNC	VGNC:45974
Bos taurus	SEC24C	VGNC	VGNC:34415
Macaca mulatta	SEC24C	VGNC	VGNC:77153
Rattus norvegicus	SEC24C	RGD	RGD:1597739
Others	SEC24C	NCBI