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Cat. No.: HY-186021

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PROTAC TEAD degrader-2

PROTAC TEAD degrader-2 (Compound 31) is an efficient TEAD1 PROTAC degrader with a DC₅₀ of 0.6 nM. PROTAC TEAD degrader-2 inhibits the YAP/TAZ-TEAD interaction, with a IC₅₀ of 1.8 nM. PROTAC TEAD degrader-2 exhibits significant selective inhibitory activity against YAP-dependent cancer cells and effectively suppresses the transcriptional activity mediated by YAP. PROTAC TEAD degrader-2 can be used for research on mesothelioma and glioma.
(Pink: TEAD1 ligand (HY-186022); Blue: Cereblon ligand (HY-122725); Black: linker (HY-76199)).

Nos produits utilisent uniquement pour la recherche. Nous ne vendons pas aux patients.

CAS No.: 2918762-17-9
Formule: C₄₉H₅₂ClF₂N₅O₇
Masse moléculaire:896.42

Stockage:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (269 KB)

PROTAC TEAD degrader-2 Chemical Structure

CAS No.: 2918762-17-9

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Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Activité biologique
- Description
- IC₅₀ & Target
Chemical Information
Pureté et documentation
Références
Calculators
Help & FAQs
Classifications
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Activité biologique

Description

PROTAC TEAD degrader-2 (Compound 31) is an efficient TEAD1 PROTAC degrader with a DC₅₀ of 0.6 nM. PROTAC TEAD degrader-2 inhibits the YAP/TAZ-TEAD interaction, with a IC₅₀ of 1.8 nM. PROTAC TEAD degrader-2 exhibits significant selective inhibitory activity against YAP-dependent cancer cells and effectively suppresses the transcriptional activity mediated by YAP. PROTAC TEAD degrader-2 can be used for research on mesothelioma and glioma^[1]. (Pink: TEAD1 ligand (HY-186022); Blue: Cereblon ligand (HY-122725); Black: linker (HY-76199)).

IC₅₀ & Target^[1]

TEAD1

0.6 nM (DC₅₀)

YAP/TAZ-TEAD

1.8 nM (IC₅₀)

Voir tous les produits spécifiques à Isoform PROTACs :

Voir tous les produits spécifiques à Isoform YAP :

Chemical Information

CAS No. 2918762-17-9
Masse moléculaire 896.42
Formule C₄₉H₅₂ClF₂N₅O₇
SMILES

O=C(C1=[C@@]([C@@]2=C3[C@H](C)[C@](C4=CC=CC=C4)(CN[C@@H]5CC[C@H](CC5)C(NCCCCCC(C=CC=C67)=C7CN(C8C(NC(CC8)=O)=O)C6=O)=O)OC3=CC(F)=C2Cl)C(F)=C(OC)C=C1)N
Livraison

Room temperature in continental US; may vary elsewhere.
Stockage

Please store the product under the recommended conditions in the Certificate of Analysis.

Pureté et documentation

Select Batch:

Pureté: 99.98%

Assay: 99.98%

ee.: 99.98%

Fiche technique (269 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Instruction de manipulation (2659 KB)

Références

[1]. Emilie Chapeau, et al. Bifunctional degraders comprising a tead binder. WO2023031801A1.

Calculators

Calculateur de molarité

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

Concentration Concentration

Volume Volume

Molecular Weight Molecular Weight

Calculateur de dilution

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

Concentration _(start) Concentration _(start)

Volume _(start) Volume _(start)

Concentration _(final) Concentration _(final)

Volume _(final) Volume _(final)

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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MOQ

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100 mg

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Activité biologique
- Description
- IC₅₀ & Target
Chemical Information
Pureté et documentation
Références

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PROTAC TEAD degrader-2

Voir tous les produits spécifiques à Isoform PROTACs

Voir tous les produits spécifiques à Isoform YAP

Activité biologique

Chemical Information

Pureté et documentation

Références

Calculators

Help & FAQs

PROTAC TEAD degrader-2 Related Classifications

HY-186021 Related Classifications