SRI-31277
SRI-31277 is a thrombospondin 1 (TSP-1) inhibitor with a human target pIC50 of 8.28 nM and in vivo activity, and exhibits a very short plasma half-life with intravenous administration.SRI-31277 inhibits interaction between TSP-1 and the latency-associated peptide (LAP) of latent TGF-β, blocking TSP-1-mediated TGF-β activation.SRI-31277 can be used for the research of multiple myeloma and fibrotic conditions.
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- CAS No.: 1637468-93-9
- Formule: C17H33N5O5
- Masse moléculaire:387.47
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Stockage:
Please store the product under the recommended conditions in the Certificate of Analysis.
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Activité biologique
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Chemical Information
- Pureté et documentation
- Références
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Help & FAQs
Activité biologique
SRI-31277 has an extremely short plasma half-life, extremely poor oral bioavailability, and multiple chiral centers that increase synthetic difficulty and potential metabolic sites, so it can serve as a lead compound[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
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CAS No. 1637468-93-9
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Masse moléculaire 387.47
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Formule C17H33N5O5
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SMILES
CC(C)C[C@@H](C(N)=O)NC([C@H](CCCCN)NC([C@H](CO)NC(C)=O)=O)=O
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Livraison
Room temperature in continental US; may vary elsewhere.
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Stockage
Please store the product under the recommended conditions in the Certificate of Analysis.
Pureté et documentation
Références
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
SRI-31277 Related Classifications
HY-182611 Related Classifications
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