1637468-93-9
1637468-93-9
Chemical Structure
SRI-31277
- CAS No.: 1637468-93-9
- Formula:C17H33N5O5
- Molecular Weight:387.47
InChIKey: JRTSFGRYHSHGEP-IHRRRGAJSA-N
SMILES: CC(C)C[C@@H](C(N)=O)NC([C@H](CCCCN)NC([C@H](CO)NC(C)=O)=O)=O
Biological Activity: SRI-31277 is a thrombospondin 1 (TSP-1) inhibitor with a human target pIC50 of 8.28 nM and in vivo activity, and exhibits a very short plasma half-life with intravenous administration.SRI-31277 inhibits interaction between TSP-1 and the latency-associated peptide (LAP) of latent TGF-β, blocking TSP-1-mediated TGF-β activation.SRI-31277 can be used for the research of multiple myeloma and fibrotic conditions[1].
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SRI-31277 | SRI-31277 is a thrombospondin 1 (TSP-1) inhibitor with a human target pIC50 of 8.28 nM and in vivo activity, and exhibits a very short plasma half-life with intravenous administration.SRI-31277 inhibits interaction between TSP-1 and the latency-associated peptide (LAP) of latent TGF-β, blocking TSP-1-mediated TGF-β activation.SRI-31277 can be used for the research of multiple myeloma and fibrotic conditions. | |||||||||||||||||||||
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