1. Membrane Transporter/Ion Channel
  2. Potassium Channel
  3. DAD

DAD 

Cat. No.: HY-136564A
Handling Instructions

DAD is a type of ion channel blocker that blocks voltage-gated potassium channels. DAD is a third-generation photoswitch that responds to visible light. DAD has the potential for restoring visual function.

For research use only. We do not sell to patients.

DAD Chemical Structure

DAD Chemical Structure

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Description

DAD is a type of ion channel blocker that blocks voltage-gated potassium channels. DAD is a third-generation photoswitch that responds to visible light. DAD has the potential for restoring visual function[1].

In Vitro

DAD is not permanently charged, and the uncharged form enables the photoswitch to rapidly and effectively cross biological barriers and thereby access and photosensitize retinal neurons. DAD selectively photosensitizes retinal neurons upstream of retinal ganglion cells (RGCs). DAD is capable of restoring retinal ganglion cell light responses to blue or white light[1].

In Vivo

Intravitreal injection of DAD restores retinal light responses and light-driven behavior to blind mice. DAD acts upstream of retinal ganglion cells, primarily conferring light sensitivity to bipolar cells. DAD is capable of generating ON and OFF visual responses in the blind retina by utilizing intrinsic retinal circuitry[1].

Molecular Weight

452.64

Formula

C₂₆H₄₀N₆O

SMILES

O=C(CN(CC)CC)NC(C=C1)=CC=C1/N=N/C2=CC=C(N(CC)CCN(CC)CC)C=C2

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

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Keywords:

DADPotassium ChannelKcsAUnchargedphotoswitchphotochromicionchannelrestoringvisualInhibitorinhibitorinhibit

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