PI3K-IN-63
PI3K-IN-63 is a selective PI3Kα inhibitor with a Ki of 0.35 nM against human targets. PI3K-IN-63 inhibits the phosphorylation of AKT at the S473 site in cellular assays. PI3K-IN-63 reduces the viability of non-small cell lung cancer cell lines carrying PIK3CA mutations. PI3K-IN-63 can be used in studies related to non-small cell lung cancer.
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- CAS. Nr.: 1202041-71-1
- Formel: C17H13Cl2N5OS
- Molecular Weight:406.29
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Speicherung:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Biologische Aktivität
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Chemical Information
- Reinheit & Dokumentation
- Verweise
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Help & FAQs
Biologische Aktivität
PI3K-IN-63 (compound 9) potently inhibits purified PI3Kα enzyme with a Ki of 0.35 nM and exhibits greater than 7000-fold selectivity over purified mTOR enzyme[1].
PI3K-IN-63 is more active in NSCLC cell lines harboring PIK3CA mutations than in other tested cancer cell lines[1].
PI3K-IN-63 (3 μM) has favorable in vitro metabolic stability (HLM ER = 0.3) and does not significantly inhibit major CYP enzymes at 3 μM[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
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CAS. Nr. 1202041-71-1
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Molecular Weight 406.29
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Formel C17H13Cl2N5OS
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SMILES
N#CC1=C(SC(C2=NN=CN2)=C1C=3C=CC(Cl)=CC3Cl)N4CCOCC4
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Versand
Room temperature in continental US; may vary elsewhere.
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Speicherung
Please store the product under the recommended conditions in the Certificate of Analysis.
Reinheit & Dokumentation
Verweise
Calculators
Konzentration (Stammlösung) × Volumen (Stammlösung) = Konzentration (Ziellösung) × Volumen (Ziellösung)
PI3K-IN-63 Related Classifications
HY-100424 Related Classifications
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