Sclerotiorin
Sclerotiorin is a reversible and uncompetitive inhibitor against soybean lipoxygenase-1 (LOX-1) (IC50: 4.2 μM). Sclerotiorin also shows antioxidant activity by scavenging free radical (ED50: 0.12 μM), and nonenzymatic lipid peroxidation inhibition activity. Sclerotiorin has antifungal activity, and also inhibits platelet aggregation. Sclerotiorin can be purified from the fermented broth of Penicillium frequentans.
For research use only. We do not sell to patients.
- CAS No.: 549-23-5
- Formula: C21H23ClO5
- Molecular Weight:390.86
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
Biological Activity
Sclerotiorin (10 μM) slows Aβ42 fibrillogenesis in vitro, detected with 6E10 antibody[2].
Sclerotiorin shows narrow spectrum activity against Gram positive bacteria, with MIC range of 128-1028 μg/mL[3].
Sclerotiorin inhibits cholesteryl ester transfer protein (CETP) activity in vitro (IC50: 19.4 μM)[4].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
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CAS No. 549-23-5
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Molecular Weight 390.86
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Formula C21H23ClO5
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SMILES
O=C1[C@](C)(OC(C)=O)C(C2=COC(/C=C/C(C)=C/[C@@H](C)CC)=CC2=C1Cl)=O
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Structure Classification
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Initial Source
Penicillium multicolor
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)