Ihh - Indian hedgehog Gene

Also Known as HHG-2

Species: Mus musculus

Gene Type: protein coding
Gene ID: 16147

Summary

Enables patched binding activity. Involved in several processes, including heart looping; positive regulation of smoothened signaling pathway; and regulation of T cell differentiation. Acts upstream of or within several processes, including animal organ development; chordate embryonic development; and positive regulation of biosynthetic process. Located in extracellular matrix. Is expressed in several structures, including alimentary system; egg cylinder; genitourinary system; limb; and skeleton. Used to study Hirschsprung's disease; annular pancreas; and brachydactyly type A1. Human ortholog(s) of this gene implicated in acrocapitofemoral dysplasia; brachydactyly type A1; retinopathy of prematurity; and syndactyly type 1. Orthologous to human IHH (Indian Hedgehog signaling molecule). [provided by Alliance of Genome Resources, Apr 2022]

Ihh Products (2)

mRNA Protein Name
NM_001313683.1 NP_001300612.1 indian hedgehog protein isoform 2 precursor
NM_010544.3 NP_034674.2 indian hedgehog protein isoform 1 preproprotein

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables patched binding IPI
IPI: Inferred from physical interaction
9811851 MGI
enables protein binding IPI
IPI: Inferred from physical interaction
10050855 MGI
Biological Process GO Annotation Evidence References Source
acts upstream of or within bone resorption IDA
IDA: Inferred from direct assay
10208865 MGI
acts upstream of or within branching involved in blood vessel morphogenesis IMP
IMP: Inferred from mutant phenotype
15689378 MGI
acts upstream of or within camera-type eye development IMP
IMP: Inferred from mutant phenotype
18582859 MGI
acts upstream of or within camera-type eye photoreceptor cell fate commitment IMP
IMP: Inferred from mutant phenotype
18582859 MGI
acts upstream of or within cartilage development IMP
IMP: Inferred from mutant phenotype
17191253 MGI
acts upstream of or within cell fate specification IMP
IMP: Inferred from mutant phenotype
18582859 MGI
acts upstream of or within cell maturation IMP
IMP: Inferred from mutant phenotype
15576404 MGI
acts upstream of cell population proliferation IMP
IMP: Inferred from mutant phenotype
16284117 MGI
acts upstream of or within chondrocyte differentiation IDA
IDA: Inferred from direct assay
15951842 MGI
acts upstream of chondrocyte differentiation IMP
IMP: Inferred from mutant phenotype
16284117 MGI
acts upstream of or within chondrocyte differentiation involved in endochondral bone morphogenesis IMP
IMP: Inferred from mutant phenotype
25639508 MGI
acts upstream of or within chondrocyte proliferation IMP
IMP: Inferred from mutant phenotype
16935278 MGI
acts upstream of or within embryo development IMP
IMP: Inferred from mutant phenotype
17881493 MGI
acts upstream of or within embryonic camera-type eye morphogenesis IMP
IMP: Inferred from mutant phenotype
18582859 MGI
acts upstream of or within embryonic digestive tract morphogenesis IMP
IMP: Inferred from mutant phenotype
10821773 MGI
acts upstream of or within embryonic digit morphogenesis IGI
IGI: Inferred from genetic interaction
20660756 MGI
acts upstream of or within embryonic digit morphogenesis IMP
IMP: Inferred from mutant phenotype
20660756 MGI
acts upstream of or within embryonic pattern specification IMP
IMP: Inferred from mutant phenotype
18582859 MGI
acts upstream of or within embryonic skeletal joint development IMP
IMP: Inferred from mutant phenotype
17191253 MGI
involved in endochondral bone morphogenesis IMP
IMP: Inferred from mutant phenotype
10465785 MGI
acts upstream of or within epithelial cell morphogenesis IMP
IMP: Inferred from mutant phenotype
18582859 MGI
acts upstream of or within epithelial cell-cell adhesion IMP
IMP: Inferred from mutant phenotype
18582859 MGI
acts upstream of or within head morphogenesis IMP
IMP: Inferred from mutant phenotype
16935278 MGI
involved in heart looping IMP
IMP: Inferred from mutant phenotype
11517919 MGI
acts upstream of or within in utero embryonic development IMP
IMP: Inferred from mutant phenotype
17881493 MGI
acts upstream of or within morphogenesis of a branching structure IMP
IMP: Inferred from mutant phenotype
11044404 MGI
acts upstream of or within multicellular organism growth IMP
IMP: Inferred from mutant phenotype
10821773 MGI
involved in negative regulation of T cell differentiation in thymus IMP
IMP: Inferred from mutant phenotype
19109233 MGI
involved in negative regulation of alpha-beta T cell differentiation IMP
IMP: Inferred from mutant phenotype
19109233 MGI
acts upstream of or within negative regulation of chondrocyte differentiation IMP
IMP: Inferred from mutant phenotype
16284117 MGI
acts upstream of or within negative regulation of eye pigmentation IMP
IMP: Inferred from mutant phenotype
17464332 MGI
involved in negative regulation of immature T cell proliferation in thymus IMP
IMP: Inferred from mutant phenotype
19109233 MGI
acts upstream of or within neuron development IMP
IMP: Inferred from mutant phenotype
10821773 MGI
acts upstream of or within ossification IMP
IMP: Inferred from mutant phenotype
11748145 MGI
acts upstream of or within osteoblast differentiation IDA
IDA: Inferred from direct assay
25639508 MGI
acts upstream of or within osteoblast differentiation IGI
IGI: Inferred from genetic interaction
25639508 MGI
acts upstream of or within osteoblast differentiation IMP
IMP: Inferred from mutant phenotype
14973297 MGI
acts upstream of or within pancreas development IGI
IGI: Inferred from genetic interaction
11044404 MGI
acts upstream of or within pancreas development IMP
IMP: Inferred from mutant phenotype
10821773 MGI
acts upstream of or within pattern specification process IMP
IMP: Inferred from mutant phenotype
9671585 MGI
involved in positive regulation of T cell differentiation in thymus IMP
IMP: Inferred from mutant phenotype
19109233 MGI
involved in positive regulation of alpha-beta T cell differentiation IMP
IMP: Inferred from mutant phenotype
19109233 MGI
acts upstream of or within positive regulation of cell population proliferation IGI
IGI: Inferred from genetic interaction
17191253 MGI
acts upstream of or within positive regulation of cell population proliferation IMP
IMP: Inferred from mutant phenotype
16284117 MGI
acts upstream of or within positive regulation of collagen biosynthetic process IDA
IDA: Inferred from direct assay
10208865 MGI
acts upstream of or within positive regulation of mesenchymal cell proliferation IMP
IMP: Inferred from mutant phenotype
18582859 MGI
acts upstream of or within positive regulation of transcription by RNA polymerase II IGI
IGI: Inferred from genetic interaction
17881493 MGI
acts upstream of positive regulation of transcription by RNA polymerase II IMP
IMP: Inferred from mutant phenotype
11517919 MGI
acts upstream of or within proteoglycan metabolic process IGI
IGI: Inferred from genetic interaction
16935278 MGI
acts upstream of or within regulation of growth IGI
IGI: Inferred from genetic interaction
19590577 MGI
acts upstream of or within retinal pigment epithelium development IMP
IMP: Inferred from mutant phenotype
18582859 MGI
acts upstream of or within skeletal system development IMP
IMP: Inferred from mutant phenotype
16278811 MGI
acts upstream of or within smooth muscle tissue development IMP
IMP: Inferred from mutant phenotype
10821773 MGI
acts upstream of or within smoothened signaling pathway IDA
IDA: Inferred from direct assay
25639508 MGI
acts upstream of or within smoothened signaling pathway IGI
IGI: Inferred from genetic interaction
19590577 MGI
involved in smoothened signaling pathway IMP
IMP: Inferred from mutant phenotype
11517919 MGI
involved in somite development IMP
IMP: Inferred from mutant phenotype
11517919 MGI
acts upstream of or within vasculature development IMP
IMP: Inferred from mutant phenotype
17881493 MGI
acts upstream of or within vitelline membrane formation IMP
IMP: Inferred from mutant phenotype
17881493 MGI
Cellular Component GO Annotation Evidence References Source
located in extracellular matrix IDA
IDA: Inferred from direct assay
11476578 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

indian hedgehog protein

Related Agents

  • Approval
  • Pre-clinical Phase

Approval

Bioactive Molecules (2)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-B0338A Rimantadine hydrochloride 98.0% Unkown
HY-B0338 Rimantadine 99.86% Unkown

Pre-clinical Phase

Bioactive Molecules (4)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-N17821 Butrin / Unkown
HY-RS06654 IHH Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS17797 Ihh Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS24265 Ihh Rat Pre-designed siRNA Set A Pre-designed Set / Unkown
Inhibitory Antibodies (1)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-P992409 MEDI-5304 Inhibitor / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Ihh NCBI NCBI:3549