MMGT1 - membrane magnesium transporter 1 Gene

Also Known as EMC5; TMEM32

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 93380

About MMGT1

This gene has 4 transcripts (splice variants), 223 orthologues, 1 paralogue and is associated with 1 phenotype. Ubiquitous expression in thyroid (RPKM 15.3), bone marrow (RPKM 10.9) and 25 other tissues.

Summary

Contributes to membrane insertase activity. Involved in protein insertion into ER membrane by stop-transfer membrane-anchor sequence and tail-anchored membrane protein insertion into ER membrane. Is integral component of endoplasmic reticulum membrane. Part of EMC complex. [provided by Alliance of Genome Resources, Apr 2022]

MMGT1 Products (2)

mRNA Protein Name
NM_001330000.2 NP_001316929.1 ER membrane protein complex subunit 5 precursor
NM_173470.3 NP_775741.1 ER membrane protein complex subunit 5 precursor

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
contributes to membrane insertase activity IMP
IMP: Inferred from mutant phenotype
29809151 GOA
enables protein binding IPI
IPI: Inferred from physical interaction
22119785 GOA
Biological Process GO Annotation Evidence References Source
involved in protein insertion into ER membrane by stop-transfer membrane-anchor sequence IDA
IDA: Inferred from direct assay
29242231 GOA
involved in protein insertion into ER membrane by stop-transfer membrane-anchor sequence IMP
IMP: Inferred from mutant phenotype
29809151 GOA
involved in tail-anchored membrane protein insertion into ER membrane IDA
IDA: Inferred from direct assay
29242231 GOA
involved in tail-anchored membrane protein insertion into ER membrane IMP
IMP: Inferred from mutant phenotype
29242231 GOA
Cellular Component GO Annotation Evidence References Source
part of EMC complex IDA
IDA: Inferred from direct assay
22119785 GOA
part of EMC complex IPI
IPI: Inferred from physical interaction
32439656 GOA
located in endoplasmic reticulum membrane IDA
IDA: Inferred from direct assay
32439656 GOA
located in membrane IDA
IDA: Inferred from direct assay
22119785 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

MMGT1 Protein Structure

MMgT

MMgT: Membrane magnesium transporter (10 - 100)

  • 0
  • 100
  • 131 a.a.
Protein Preferred Names Protein Names

ER membrane protein complex subunit 5

  • transmembrane protein 32

MMGT1 Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method References
Intra
MMGT1 Q8N4V1 SLC35B4 Homo sapiens Q969S0
Validated Y2H
32296183
Intra
MMGT1 Q8N4V1 DEFB127 Homo sapiens Q9H1M4
Validated Y2H
32296183
Intra
MMGT1 Q8N4V1 SLC38A7 Homo sapiens Q9NVC3
Validated Y2H
32296183
Intra
MMGT1 Q8N4V1 NINJ2 Homo sapiens Q9NZG7
Validated Y2H
32296183
Intra
MMGT1 Q8N4V1 ADGRE2 Homo sapiens Q9UHX3
Validated Y2H
32296183
Intra
MMGT1 Q8N4V1 PLPP6 Homo sapiens Q8IY26
Y2H Array
32296183
Intra
MMGT1 Q8N4V1 MFF Homo sapiens Q9GZY8-5
Validated Y2H
32296183
Intra
MMGT1 Q8N4V1 TMEM254 Homo sapiens Q8TBM7
Validated Y2H
32296183
Intra
MMGT1 Q8N4V1 TMEM254 Homo sapiens Q8TBM7
Y2H Array
32296183
Intra
MMGT1 Q8N4V1 C4orf3 Homo sapiens Q8WVX3-2
Validated Y2H
32296183
Intra
MMGT1 Q8N4V1 LNPEP Homo sapiens Q9UIQ6-2
Validated Y2H
32296183
Intra
MMGT1 Q8N4V1 TMEM229B Homo sapiens Q8NBD8
Validated Y2H
32296183
Intra
MMGT1 Q8N4V1 NDUFA3 Homo sapiens O95167
Anti Tag CoIP
35271311
Intra
MMGT1 Q8N4V1 TMEM14C Homo sapiens Q9P0S9
Validated Y2H
32296183
Intra
MMGT1 Q8N4V1 TMEM86B Homo sapiens Q8N661
Validated Y2H
32296183
Intra
MMGT1 Q8N4V1 TMEM14A Homo sapiens Q9Y6G1
Validated Y2H
32296183
Intra
MMGT1 Q8N4V1 EMC6 Homo sapiens Q9BV81
Validated Y2H
32296183
Intra
MMGT1 Q8N4V1 EMC6 Homo sapiens Q9BV81
Pull Down
22119785
Intra
MMGT1 Q8N4V1 TMEM60 Homo sapiens Q9H2L4
Validated Y2H
32296183
Intra
MMGT1 Q8N4V1 TECR Homo sapiens Q9NZ01
Validated Y2H
32296183
Intra
MMGT1 Q8N4V1 FIS1 Homo sapiens Q9Y3D6
Validated Y2H
32296183
Intra
MMGT1 Q8N4V1 EMC2 Homo sapiens Q15006
Pull Down
22119785
Intra
MMGT1 Q8N4V1 EMC2 Homo sapiens Q15006
Anti Tag CoIP
35271311
Intra
MMGT1 Q8N4V1 EMC2 Homo sapiens Q15006
Anti Tag CoIP
26496610
Intra
MMGT1 Q8N4V1 EMC2 Homo sapiens Q15006
Anti Tag CoIP
32439656
Intra
MMGT1 Q8N4V1 EMC2 Homo sapiens Q15006
Anti Tag CoIP
33961781
Intra
MMGT1 Q8N4V1 AGR3 Homo sapiens Q8TD06
Validated Y2H
32296183
Intra
MMGT1 Q8N4V1 SLC7A14 Homo sapiens Q8TBB6
Validated Y2H
32296183
Intra
MMGT1 Q8N4V1 FXYD6 Homo sapiens Q9H0Q3
Validated Y2H
32296183
Intra
MMGT1 Q8N4V1 STX8 Homo sapiens Q9UNK0
Validated Y2H
32296183
Intra
MMGT1 Q8N4V1 MFSD3 Homo sapiens Q96ES6
Validated Y2H
32296183
Intra
MMGT1 Q8N4V1 INSIG2 Homo sapiens Q9Y5U4
Validated Y2H
32296183
Intra
MMGT1 Q8N4V1 RUSF1 Homo sapiens Q96GQ5
Validated Y2H
32296183
Intra
MMGT1 Q8N4V1 PEX16 Homo sapiens Q9Y5Y5
Validated Y2H
32296183
Cross: Cross-species interaction Intra: Intraspecies interaction

Recombinant MMGT1 Proteins

Cat. No. Product Name Accession Purity
HY-P77087 MMGT1 Protein, Human (HEK293, His) Q8N4V1-1/NP_775741.1 (E66-R131) ≥ 95%, as determined by reducing SDS-PAGE.

Related Diseases

Diseases Alias
Chromosome 15q11.2 Deletion Syndrome

  • 15q11.2 Microdeletion Syndrome

  • 15q11.2 Bp1-Bp2 Microdeletion Syndrome

  • Del(15)(Q11.2)

  • Monosomy 15q11.2

  • 15q11.2 Microdeletion

  • Chromosome 15q11.2 Deletion

  • Chromosome 15q11.2 Microdeletion

  • Chromosome Deletion Syndrome 15q11.2

  • Microdeletion 15q11.2

  • Duplication 15q11-Q13 Syndrome
Fundus Dystrophy

  • Retinal Dystrophy

  • Retinal Dystrophies

  • Dystrophy, Retinal
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (3)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS08515 MMGT1 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS19716 Mmgt1 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS26212 Mmgt1 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Mus musculus MMGT1 MGD MGI:2384305
Felis catus MMGT1 VGNC VGNC:63536
Bos taurus MMGT1 VGNC VGNC:31516
Rattus norvegicus MMGT1 RGD RGD:1566339
Others MMGT1 NCBI