Ferroptosis inducer-7
Ferroptosis inducer-7 is an orally active and selective ferroptosis inducer via inositol 1,4,5-trisphosphate receptor (IP3R)/calcium release-activated calcium channel protein (ORAI). Ferroptosis inducer-7 exhibits a notable effect in alleviating anemia symptoms, suppressing bone marrow CTLs activation, and improving hematopoietic function in immune-mediated bone marrow failure. Ferroptosis inducer-7 can be studied in research for aplastic anemia.
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- No. CAS: 2723569-00-2
- Fòrmula: C29H31NO6
- Peso molecular:489.56
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Actividad biológica
Ferroptosis inducer-7 (Compound 3a-M1) (1-10 μM, 72 h) significantly inhibits the proliferation of CD8+ T cells, as well as the release of IFN-γ and TNF-α in lymph nodes of BALB/c mice[1].
Ferroptosis inducer-7 (7.5-480 μM, 72 h) selectively inhibits the proliferation of cytotoxic lymphocyte line-2 (CTLL-2) compared to other immune cell lines[1].
Ferroptosis inducer-7 (7.5-30 μM, 16 h) suggests the inhibition of CTL function is due to the activation of Ferroptosis in CTLL-2 treated with IL-2[1].
Ferroptosis inducer-7 (10 μM, 45 min) increases the extracellular Ca2+ influx om CTLs, which is triggered by the IP3R /ORAI calcium channels[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Cell Line:IL-2 stimulated CTLL-2 cell line
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Concentration:7.5-30 μM
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Incubation Time:16 h
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Result:Showed a significant increase in the phosphorylation levels of mitogen-activated protein kinase, ERK and p38.
Activated the MEK/ERK and p38 MAPK signaling pathway.
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Cell Line:IL-2 stimulated CTLL-2 cell line
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Concentration:7.5-480 μM
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Incubation Time:72 h
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Result:Showed the IC50 of Ferroptosis inducer-7 for IL-2-treated CTLL-2 (37.87 μM) was much lower than that for other immune cell lines, such as THP-1 (124.7 μM), HL-60 (132.6 μM), RAW264.7 (491.8 μM), HepG2 (491.9 μM), NRK-52E (705.1 μM), and IEC-6 (84.29 μM).
Ferroptosis inducer-7 (5-15 mg/kg, p.o., 21 d) improves survival rate, alleviates anemia symptoms, and improves hematopoietic function of immune-mediated bone marrow failure model in C57BL/6J mice model, particularly during the early stages of bone marrow failure[1].
Ferroptosis inducer-7 (5-15 mg/kg, p.o., one single dose) suppresses the proportion of T cells, especially CD8+ cells and CD8+/ CD4+ ratio in the bone marrow of aplastic anemia C57BL/6J mice[1].
Ferroptosis inducer-7 (10 g/kg, p.o., one single dose) causes no abnormalities in mice models, indicating the maximum tolerated dose exceeds 10 g/kg[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Animal Model:Immune-mediated bone marrow failure BALB/c mice model[1]
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Dosage:10 mg/kg, 14 d
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Administration:Oral gavage (p.o.)
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Result:Elevated body weight, peripheral red blood cells, hemoglobin levels, and platelet cells in mice.
Improved histopathological changes in the bone marrow, including increased nucleated cells, a restored nucleated-to-red blood cell ratio and a decrease in abnormal proportion of lymphocytes.
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Animal Model:Aplastic anemia C57BL/6J mice[1]
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Dosage:5-15 mg/kg, one single dose
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Administration:Oral gavage (p.o.)
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Result:Reduced the proportion of effector CD8+ T cells, and increased memory CD8+ T cells.
Suppressed the level of IFN-γ and hyperactivation of CTLs in the bone marrow of AA mice.
Chemical Information
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No. CAS 2723569-00-2
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Peso molecular 489.56
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Fòrmula C29H31NO6
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SMILES
O=C(/C=C/C1=CC=CC=C1)OC2=C3[C@]45[C@@](C=C(C(C5)=O)OC)([H])[C@](N(CC4)C)([H])CC3=C(C=C2OC)CO
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Envío
Room temperature in continental US; may vary elsewhere.
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Almacenamiento
Please store the product under the recommended conditions in the Certificate of Analysis.
Pureza y Documentación
Referencias
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Ferroptosis inducer-7 Related Classifications
HY-172803 Related Classifications
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