PTK6 - protein tyrosine kinase 6 Gene

Also Known as BRK

Species: Homo sapiens

Gene Type: protein coding

Gene ID: 5753

About PTK6

Cytogenetic location: 20q13.33 Genomic coordinates (GRCh38): 20:63,528,001-63,537,376 (from NCBI)

This gene has 2 transcripts (splice variants), 175 orthologues, 32 paralogues and is associated with 50 phenotypes. Biased expression in esophagus (RPKM 27.3), skin (RPKM 21.0) and 9 other tissues.

Summary

The protein encoded by this gene is a cytoplasmic nonreceptor protein kinase which may function as an intracellular signal transducer in epithelial tissues. Overexpression of this gene in mammary epithelial cells leads to sensitization of the cells to epidermal growth factor and results in a partially transformed phenotype. Expression of this gene has been detected at low levels in some breast tumors but not in normal breast tissue. The encoded protein has been shown to undergo autophosphorylation. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jan 2012]

PTK6 Products (2)

mRNA	Protein	Name
NM_001256358.2	NP_001243287.1	protein-tyrosine kinase 6 isoform 2
NM_005975.4	NP_005966.1	protein-tyrosine kinase 6 isoform 1

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Références	Source
enables identical protein binding	IPI IPI: Inferred from physical interaction	15056653	GOA
enables non-membrane spanning protein tyrosine kinase activity	IDA IDA: Inferred from direct assay	10913193	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	10913193	GOA
enables protein tyrosine kinase activity	EXP EXP: Inferred from Experiment	16568091	GOA

Biological Process GO Annotation	Evidence	Références	Source
involved in cell migration	IDA IDA: Inferred from direct assay	15572663	GOA
involved in cellular response to retinoic acid	IMP IMP: Inferred from mutant phenotype	17910947	GOA
involved in negative regulation of protein tyrosine kinase activity	IDA IDA: Inferred from direct assay	15539407	GOA
involved in positive regulation of neuron projection development	IMP IMP: Inferred from mutant phenotype	17910947	GOA
involved in protein autophosphorylation	IMP IMP: Inferred from mutant phenotype	12121988	GOA
involved in tyrosine phosphorylation of STAT protein	IDA IDA: Inferred from direct assay	16568091	GOA

Cellular Component GO Annotation	Evidence	Références	Source
located in cytoplasm	IDA IDA: Inferred from direct assay	15572663	GOA
located in nucleus	IDA IDA: Inferred from direct assay	10913193	GOA
located in ruffle	IDA IDA: Inferred from direct assay	15572663	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

PTK6 Protein Structure

Pkinase_Tyr

0
100
200
300
350 a.a.

Protein Preferred Names	Protein Names
protein-tyrosine kinase 6	PTK6 protein tyrosine kinase 6

PTK6 Protein-protein interaction Information

Type	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	Références
Intra	PTK6	Q13882	KIAA1217	Homo sapiens	Q5T5P2-6	Validated Y2H	32296183
Intra	PTK6	Q13882	KIAA1217	Homo sapiens	Q5T5P2-6	Y2H Prey Pooling	32296183
Intra	PTK6	Q13882	KIAA1217	Homo sapiens	Q5T5P2-6	Y2H Array	32296183
Intra	PTK6	Q13882	PRDM6	Homo sapiens	Q9NQX0	Y2H Prey Pooling	32296183
Intra	PTK6	Q13882	PRDM6	Homo sapiens	Q9NQX0	Validated Y2H	32296183
Intra	PTK6	Q13882	PRDM6	Homo sapiens	Q9NQX0	Y2H Array	32296183
Intra	PTK6	Q13882	KIT	Homo sapiens	P10721	FPS	24728074
Intra	PTK6	Q13882	EFHC2	Homo sapiens	Q5JST6	Y2H Prey Pooling	25416956
Intra	PTK6	Q13882	DDX17	Homo sapiens	Q92841	Anti Tag CoIP	31980649
Intra	PTK6	Q13882	PTK6	Homo sapiens	Q13882	Protein Kinase Assay	18719096
Intra	PTK6	Q13882	EFHC2	Homo sapiens	Q5JST6	Y2H Prey Pooling	32296183
Intra	PTK6	Q13882	EXOC5	Homo sapiens	O00471	Y2H Prey Pooling	32296183
Intra	PTK6	Q13882	PTK6	Homo sapiens	Q13882	SPR	15056653
Intra	PTK6	Q13882	EFHC2	Homo sapiens	Q5JST6	Y2H Array	31515488
Intra	PTK6	Q13882	PTK6	Homo sapiens	Q13882	NMR	19401189
Intra	PTK6	Q13882	EXOC5	Homo sapiens	O00471	Y2H Array	32296183
Intra	PTK6	Q13882	EFHC2	Homo sapiens	Q5JST6	Validated Y2H	32296183
Intra	PTK6	Q13882	EFHC2	Homo sapiens	Q5JST6	Y2H Array	25416956
Intra	PTK6	Q13882	EXOC5	Homo sapiens	O00471	Validated Y2H	25416956
Intra	PTK6	Q13882	EFHC2	Homo sapiens	Q5JST6	Y2H Array	32296183
Intra	PTK6	Q13882	ANKRD55	Homo sapiens	Q3KP44	Y2H Array	32296183
Intra	PTK6	Q13882	ANKRD55	Homo sapiens	Q3KP44	Y2H Prey Pooling	32296183
Intra	PTK6	Q13882	ANKRD55	Homo sapiens	Q3KP44	Validated Y2H	32296183
Intra	PTK6	Q13882	SLA	Homo sapiens	Q13239-3	Y2H Array	32296183
Intra	PTK6	Q13882	SLA	Homo sapiens	Q13239-3	Y2H Prey Pooling	32296183
Intra	PTK6	Q13882	DTX3	Homo sapiens	Q8N9I9	Y2H Array	32296183
Intra	PTK6	Q13882	DTX3	Homo sapiens	Q8N9I9	Y2H Prey Pooling	32296183
Intra	PTK6	Q13882	DTX3	Homo sapiens	Q8N9I9	Validated Y2H	32296183
Intra	PTK6	Q13882	ACTN3	Homo sapiens	Q08043	Y2H Array	32296183
Intra	PTK6	Q13882	ACTN3	Homo sapiens	Q08043	Y2H Prey Pooling	32296183
Intra	PTK6	Q13882	CDC37	Homo sapiens	Q16543	Anti Tag CoIP	31980649
Intra	PTK6	Q13882	REL	Homo sapiens	Q04864	Y2H Prey Pooling	25416956
Intra	PTK6	Q13882	HSP90AB1	Homo sapiens	P08238	Anti Tag CoIP	31980649
Intra	PTK6	Q13882	SFPQ	Homo sapiens	P23246	SLCA	19439179
Intra	PTK6	Q13882	SFPQ	Homo sapiens	P23246	GMS	19439179
Intra	PTK6	Q13882	SFPQ	Homo sapiens	P23246	Anti Bait CoIP	19439179
Intra	PTK6	Q13882	GAB1	Homo sapiens	Q13480	FPS	24728074
Intra	PTK6	Q13882	MYOZ3	Homo sapiens	Q8TDC0	Validated Y2H	32296183
Intra	PTK6	Q13882	ERBB2	Homo sapiens	P04626	Anti Bait CoIP	18719096
Intra	PTK6	Q13882	ERBB2	Homo sapiens	P04626	PLA	20700126
Intra	PTK6	Q13882	FCHO1	Homo sapiens	O14526	Y2H Array	31515488
Intra	PTK6	Q13882	KHDRBS2	Homo sapiens	Q5VWX1	Y2H Array	25416956
Intra	PTK6	Q13882	KHDRBS2	Homo sapiens	Q5VWX1	Y2H Array	31515488
Intra	PTK6	Q13882	KHDRBS2	Homo sapiens	Q5VWX1	Y2H Prey Pooling	25416956
Intra	PTK6	Q13882	CBLB	Homo sapiens	Q13191	Y2H Prey Pooling	32296183
Intra	PTK6	Q13882	CBLB	Homo sapiens	Q13191	Y2H Array	32296183
Intra	PTK6	Q13882	DDX17	Homo sapiens	Q92841	Validated Y2H	32296183
Intra	PTK6	Q13882	DDX17	Homo sapiens	Q92841	Y2H Array	32296183
Intra	PTK6	Q13882	DDX17	Homo sapiens	Q92841	Y2H Prey Pooling	32296183
Intra	PTK6	Q13882	IKZF3	Homo sapiens	Q9UKT9	Y2H Prey Pooling	32296183
Intra	PTK6	Q13882	IKZF3	Homo sapiens	Q9UKT9	Validated Y2H	32296183
Intra	PTK6	Q13882	IKZF3	Homo sapiens	Q9UKT9	Y2H Array	32296183
Intra	PTK6	Q13882	ZNF341	Homo sapiens	Q9BYN7	Y2H Prey Pooling	32296183
Intra	PTK6	Q13882	ZNF341	Homo sapiens	Q9BYN7	Validated Y2H	32296183
Intra	PTK6	Q13882	ZNF341	Homo sapiens	Q9BYN7	Y2H Array	32296183
Intra	PTK6	Q13882	WASL	Homo sapiens	O00401	Validated Y2H	25416956

Cross: Cross-species interaction Intra: Intraspecies interaction

Recombinant PTK6 Proteins

Cat. No.	Nom du produit	Accession	Pureté
HY-P75470	Brk/PTK6 Protein, Human (sf9, GST)	Q13882-1 (M1-T451)	≥ 85%, as determined by reducing SDS-PAGE.

PTK6 Anticorps

Cat. No.	Nom du produit	Application	Reactivity
HY-P81458	Brk/PTK6 Antibody (YA1203)	IHC-P	Human
HY-P81458A	Brk/PTK6 Antibody (YA1203)(PBS only)	IHC-P	Human
HY-P84558	Brk/PTK6 Antibody (YA4255)	WB, ELISA	Human
HY-P84558A	Brk/PTK6 Antibody (YA4255)(PBS only)	WB, ELISA	Human
HY-P85066	Brk/PTK6 Antibody (YA4758)	WB, ELISA	Human

Related Diseases

Diseases	Alias
Ovary Serous Adenocarcinoma	Malignant Ovarian Serous Tumor Serous Carcinoma Of Ovary
Breast Cancer	Breast Carcinoma Male Breast Cancer Breast Cancer, Familial Malignant Neoplasm Of Breast Breast Cancer, Susceptibility To Breast Cancer, Early-Onset Malignant Tumor Of Breast Carcinoma Of Male Breast Breast Cancer, Invasive Ductal Breast Cancer, Protection Against Breast Cancer, Somatic Breast Cancer, Male Breast Cancer, Lobular, Somatic Breast Tumor Mammary Cancer Mammary Tumor Malignant Neoplasm Of Male Breast Mammary Carcinoma Male Breast Carcinoma Familial Cancer Of Breast Invasive Ductal Breast Carcinoma Breast Cancer Susceptibility Breast Cancer, Male, Susceptibility To Breast Cancer, Early-Onset, Susceptibility To Malignant Tumor Of The Breast Mammary Neoplasm Primary Breast Cancer Neoplasm Of Male Breast Carcinoma Of Breast Breast Cancer In Men Familial Breast Cancer Cancer Of Breast BC Breast Cancer Familial Breast Cancer Familial Male Breast Cancer, Familial Male Breast Male Carcinoma Breast Neoplasms Breast Neoplasms, Male Mammary Tumors Mammary Carcinomas Cancer, Breast Cancer, Breast, Susceptibility Invasive Breast Ductal Carcinoma Breast Neoplasm Susceptibility To Breast Cancer Mammary Neoplasms Animal Mammary Neoplasms Primary Malignant Neoplasm Of Breast Infiltrating Ductal Carcinoma Of Breast Infiltrating Duct Carcinoma Of Unspecified Site Infiltrating Ductular Carcinoma Of Unspecified Site Invasive Breast Carcinoma Of No Special Type Microinvasive Carcinoma Of Breast Carcinoma With Apocrine Differentiation
Charge Syndrome	Charge Association Hall-Hittner Syndrome Charge Association--Coloboma, Heart Anomaly, Choanal Atresia, Retardation, Genital And Ear Anomalies Hhs Coloboma, Heart Anomaly, Choanal Atresia, Restriction Of Growth And Development, Genital And Ear Anomalies Coloboma-Heart Defects-Atresia Choanae-Retardation Of Growth And Development-Genitourinary Problems-Ear Abnormalities Syndrome CHARGES
Aggressive Systemic Mastocytosis	Asm Lymphadenopathic Mastocytosis With Eosinophilia

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (21)

Cat. No.	Nom du produit	Effect	Pureté	Rare Diseases
HY-110244	Tilfrinib	Inhibitor	99.39%	Unkown
HY-N0616	Trifolirhizin		98.37%	Unkown
HY-108333	SB-633825	Inhibitor	98.05%	Unkown
HY-148065	FMF-06-098-1	Inhibitor	98.77%	Unkown
HY-147219A	SIAIS164018 hydrochloride		98.06%	Unkown
HY-171830	MS105		98.27%	Unkown
HY-115514A	BRK inhibitor P21d hydrochloride	Inhibitor	99.77%	Unkown
HY-122664	XMU-MP-2		99.29%	Unkown
HY-139660	PTK6 ligand-1		95.03%	Unkown
HY-147219	SIAIS164018		/	Unkown
HY-RS11403	PTK6 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-163214	(S)-PROTAC PTK6 ligand-1-(2S,4R)-O-CH2-O-hygric acid		/	Unkown
HY-163215	(S)-PROTAC PTK6 ligand-O-4,4-dimethylpiperidine-Boc		/	Unkown
HY-163216	PROTAC PTK6 ligand-O-4,4-dimethylpiperidine-Boc		/	Unkown
HY-163217	PROTAC PTK6 ligand-2,7-diazaspiro[3.5]nonane-Boc		/	Unkown
HY-163218	PROTAC PTK6 ligand-1-(2S,4R)-O-CH2-O-hygric acid		/	Unkown
HY-163224	(S)-PROTAC PTK6 ligand-O-C2-O-piperidine-Boc		/	Unkown
HY-163228	PROTAC PTK6 ligand-O-C2-O-piperidine-Boc		/	Unkown
HY-178460	BRK/PTK6-IN-1	Inhibitor	/	Unkown
HY-RS17542	Ptk6 Mouse Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS24000	Ptk6 Rat Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Macaca mulatta	PTK6	VGNC	VGNC:84902
Felis catus	PTK6	VGNC	VGNC:81161
Mus musculus	PTK6	MGD	MGI:99683
Bos taurus	PTK6	VGNC	VGNC:33520
Rattus norvegicus	PTK6	RGD	RGD:1309098
Others	PTK6	NCBI