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SB-633825 

Cat. No.: HY-108333 Purity: 98.17%
Handling Instructions

SB-633825 is a potent and ATP-competitive inhibitor of TIE2, LOK (STK10) and BRK with IC50s of 3.5 nM, 66 nM, 150 nM, respectively. SB-633825 can inhibit cancer cell growth and angiogenesis.

For research use only. We do not sell to patients.

SB-633825 Chemical Structure

SB-633825 Chemical Structure

CAS No. : 956613-01-7

Size Price Stock Quantity
10 mM * 1 mL in DMSO USD 426 In-stock
Estimated Time of Arrival: December 31
5 mg USD 400 In-stock
Estimated Time of Arrival: December 31
10 mg USD 680 In-stock
Estimated Time of Arrival: December 31
50 mg USD 1900 In-stock
Estimated Time of Arrival: December 31
100 mg USD 3000 In-stock
Estimated Time of Arrival: December 31
200 mg   Get quote  
500 mg   Get quote  

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Based on 1 publication(s) in Google Scholar

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Description

SB-633825 is a potent and ATP-competitive inhibitor of TIE2, LOK (STK10) and BRK with IC50s of 3.5 nM, 66 nM, 150 nM, respectively. SB-633825 can inhibit cancer cell growth and angiogenesis[1].

IC50 & Target

IC50: 3.5 nM (TIE2), 66 nM (LOK) and 150 nM (BRK)[1]

In Vitro

SB-633825 inhibits TIE2 Tyrosine-protein kinase (TIE2), lymphocyte-oriented kinase (LOK; STK10) and breast tumor kinase (Brk; PTK6)[1].
SB-633825 inhibits LOK to 44% maximal activity and TIE2 to 75% maximal activity at 0.1 µM[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Molecular Weight

483.58

Formula

C₂₈H₂₅N₃O₃S

CAS No.

956613-01-7

SMILES

O=S(C1=CC=C(C2=NC(C3=CC=NC=C3)=C(C4=CC=C5C=C(OC)C=CC5=C4)N2C)C(C)=C1)(C)=O

Shipping

Room temperature in continental US; may vary elsewhere.

Storage
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : 9.62 mg/mL (19.89 mM; Need ultrasonic)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 2.0679 mL 10.3396 mL 20.6791 mL
5 mM 0.4136 mL 2.0679 mL 4.1358 mL
10 mM 0.2068 mL 1.0340 mL 2.0679 mL
*Please refer to the solubility information to select the appropriate solvent.
References
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Keywords:

SB-633825SB633825SB 633825OthersTIE2LOKSTK10BRKcancerangiogenesislymphocyte-orientedkinasebreasttumorPTK6protein-tyrosine6Inhibitorinhibitorinhibit

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Product Name:
SB-633825
Cat. No.:
HY-108333
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